Reference SummaryMoser AR, Proc Natl Acad Sci U S A 1993 Oct 1;90(19):8977-81

Title

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.

Authors

Moser AR; Mattes EM; Dove WF; Lindstrom MJ; Haag JD; Gould MN

Journal

Proc Natl Acad Sci U S A

Volume

90

Issue

19

Year

1993

Pages

8977-81

Abstract

ApcMin (Min, multiple intestinal neoplasia) is a point mutation in the murine homolog of the APC gene. Min/+ mice develop multiple intestinal adenomas, as do humans carrying germ-line mutations in APC. Female mice carrying Min are also prone to develop mammary tumors. Min/+ mammary glands are more sensitive to chemical carcinogenesis than are +/+ mammary glands. Transplantation of mammary cells from Min/+ or +/+ donors into +/+ hosts demonstrates that the propensity to develop mammary tumors is intrinsic to the Min/+ mammary cells. Long-term grafts of Min/+ mammary glands also gave rise to focal alveolar hyperplasias, indicating that the presence of the Min mutation also has a role in the development of these lesions.

Links

J:15101 – Mouse Genome Informatics
8415640 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AKB6F1-ApcMin/+ Intestine adenoma Intestine

very high

(AKB6F1 x B6)F1-ApcMin/+ Intestine adenoma Intestine

very high

(CASTB6F1 x B6)F1-ApcMin/+ Intestine adenoma Intestine

very high

C57BL/6J-ApcMin/+ Mammary gland carcinoma Mammary gland

observed

AKB6F1-ApcMin/+ Mammary gland carcinoma Mammary gland

20

(AKB6F1 x B6)F1-ApcMin/+ Mammary gland carcinoma Mammary gland

7.7

(CASTB6F1 x B6)F1-ApcMin/+ Mammary gland carcinoma Mammary gland

11

C57BL/6J-ApcMin/+ Mammary gland carcinoma
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

0 - 37.5

(AKR/J x C57BL/6J)F1 Mammary gland tumor Mammary gland

0

C57BL/6J Mammary gland tumor Mammary gland

0

(AKB6F1 x B6)F1 Mammary gland tumor Mammary gland

0

(CASTB6F1 x B6)F1 Mammary gland tumor Mammary gland

0

C57BL/6J Mammary gland tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

0

C57BL/6J-ApcMin/+ Mammary gland tumor Mammary gland

0