Patient Derived XenograftSearch Form

Patient Derived Xenograft (PDX) models for cancer research are created by the implantation of human cells and tumor tissue into immune compromised mouse hosts. PDX models provide a platform for in vivo cancer biology studies and pre-clinical cancer drug efficacy testing. The current state of the art mouse host is the "NOD-SCID-Gamma2" (NSG) mouse. NSG mice lack mature T and B cells, have no functional natural killer cells, and are deficient in both innate immunity and cytokine signaling.

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Help and Documentation

Search by PDX model identifier
 eg. TM00001
Search by primary cancer site
Primary Site
Limit results to models with dosing study data
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Search by diagnosis
Diagnosis
Search by dosing study results
Drug
Response
Search by tumor mutation burden (TMB) score range
   ( TMB > 22 is considered high.)
<=  TMB  <=
Search by fusion gene
Fusion Gene
Search by gene variants (in engrafted tumors)
Gene
Variants
No variants for selected gene.
Display gene expression across PDX models for a gene
Gene
Search by gene amplification and deletion
Gene