Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-09-15
MTB 3.0
 
HelpHelp and Documentation Patient Derived Xenograft PDX Like Me Search
 Patient Derived Xenograft (PDX) models for cancer research are created by the implantation of human cells and tumor tissue into immune compromised mouse hosts. PDX models provide a platform for in vivo cancer biology studies and pre-clinical cancer drug efficacy testing. The current state of the art mouse host is the "NOD-SCID-Gamma2" (NSG) mouse. NSG mice lack mature T and B cells, have no functional natural killer cells, and are deficient in both innate immunity and cytokine signaling.
 
NSG Mouse

Use PDX Like Me to search for PDX models with tumor samples that meet multiple genomic criteria.
Molecular profiles can combine mutation, expression, and/or copy number aberration criteria.
Multiple profiles can be searched at one time.

Learn how to use PDX Like Me

Example search:
CASE 1
KRAS:AMP
TP53:MUT=A159V
ALB:DEL
KIT:EXP>2.5
Output options:



Enter Case information here:
Return results as a CSV file
Include models with clinically relevant variants for supplied genes
If searching by CNV display log ratio ploidy values
If searching by expression level display Z score percentile rank values