PDX Model DetailsTM00386

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PDX Model Summary

Model Details

Model ID (Previous ID)
TM00386 (BR0555F)
Initial Diagnosis
Invasive ductal carcinoma
Final Diagnosis
Invasive ductal carcinoma
Stage/Grade
AJCC IV / Grade:2
Primary Site
Breast
Sample Site
Breast
Tumor Type
Primary Malignancy

Patient

Sex
Female
Age (at time of tissue collection)
86
Race/Ethnicity
White / Not Reported
Treatment Naïve?
No
Current Smoker/Former Smoker
No / No

Engraftment

Host Strain
NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ
(aka NSG or NOD Scid gamma)
Sample Type
Surgical resection (fragment)
Engraftment Site
no data

Molecular Data (Engrafted Tumor)

Variants

Gene Expression

Platforms: hg10st

Gene CNV

CNV Plots

Tumor Mutation Burden

Sample BR0555F294P0 from passage P0 has a TMB score of 5.66
TMB Range
0.0-304.42 (across all JAX PDX models; TMB > 22 is considered high)

Microsatellite Instability

Sample:BR0555F294P0 from passage P0     Score:MSI-S

Gene Fusion

no data

Model Characterization

Histology

Tumor Markers:
Patient is ER positive; PR positive; HER2 (ERRB2) negative. P0 and P1 tumors reflect the marker status of the patient tumor. P4 pathology consistent with poorly differentiated carcinoma.
Pathologist:
Dr. Regina Gandour-Edwards, University of California, Davis

Patient tumor for PDX model TM00386.

Patient tumor for PDX model TM00386; PR marker (positive)

Patient tumor for PDX model TM00386; ER marker (positive)

P0 tumor #294 for PDX model TM00386.

P0 tumor #294 for PDX model TM00386; PR marker (positive)

P0 tumor #294 for PDX model TM00386; ER marker (positive)

P1 tumor #294 for PDX model TM00386.

P1 tumor #294 for PDX model TM00386.

P1 tumor #294 for PDX model TM00386; PR marker (positive)

P1 tumor #294 for PDX model TM00386; ER marker (positive)

P4 tumor F294 ID023 for PDX model TM00386 stained for H&E.

P4 tumor F294 ID023 for PDX model TM00386 stained for AE1/AE3. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for CD45. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for Ki67. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for AR. Staining was negative.

P4 tumor F294 ID023 for PDX model TM00386 stained for ER. Staining was positive.

P4 tumor F294 ID023 for PDX model TM00386 stained for ERBB2 (HER2). Staining was negative.

P4 tumor F294 ID023 for PDX model TM00386 stained for PR. Staining was negative.

P5 tumor F294 ID029 for PDX model TM00386 stained for H&E.

P5 tumor F294 ID029 for PDX model TM00386 stained for AE1/AE3.

P5 tumor F294 ID029 for PDX model TM00386 stained for CD45.

P5 tumor F294 ID029 for PDX model TM00386 stained for Ki67.

P5 tumor F294 ID029 for PDX model TM00386 stained for AR.

P5 tumor F294 ID029 for PDX model TM00386 stained for ER.

P5 tumor F294 ID029 for PDX model TM00386 stained for ERBB2 (HER2).

P5 tumor F294 ID029 for PDX model TM00386 stained for PR.

Dosing Studies

Circos Plots


Circos plot for P0 tumor #294 from PDX model TM00386 (aka, BR0555F)