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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Trp53
Gene Name transformation related protein 53
Mouse Chromosome 11
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Trp53tm1.1Brn-sm
targeted mutation 1.1 (somatic), Anton Berns
Bone osteosarcoma None (spontaneous) (3)
Bone osteosarcoma Genetic Modification (1)
CNS - Brain - Choroid plexus carcinoma Genetic Modification (3)
CNS - Brain - Choroid plexus tumor Genetic Modification (2)
CNS - Brain tumor Genetic Modification (1)
CNS - Brain - Undifferentiated cell medulloblastoma None (spontaneous) (1)
Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (2)
Leukocyte lymphoma Genetic Modification (7)
Leukocyte - Monocyte leukemia - myelocytic Genetic Modification (5)
Liver - Bile duct cholangiocarcinoma Genetic Modification (5)
Liver hepatocellular carcinoma None (spontaneous) (2)
Liver hepatoma Genetic Modification (5)
Liver - Oval cell hyperplasia Genetic Modification (5)
Lung adenocarcinoma Genetic Modification (8)
Lung adenocarcinoma - neuroendocrine Genetic Modification (2)
Lung carcinoma - adenosquamous Genetic Modification (2)
Lung carcinoma - large cell (LCC) Genetic Modification (2)
Lung carcinoma - large cell neuroendocrine Genetic Modification (2)
Lung carcinoma - small cell lung (SCLC) Chemical/Drug (2)
Lung carcinoma - small cell lung (SCLC) Genetic Modification (15)
Lung squamous cell carcinoma Genetic Modification (2)
Lung tumor Genetic Modification (13)
Mammary gland adenocarcinoma None (spontaneous) (3)
Mammary gland carcinoma None (spontaneous) (7)
Mammary gland carcinoma in situ None (spontaneous) (1)
Mammary gland carcinoma - lobular None (spontaneous) (3)
Mammary gland carcinoma - poorly differentiated None (spontaneous) (2)
Mammary gland carcinoma - solid None (spontaneous) (2)
Mammary gland carcinoma - well-differentiated None (spontaneous) (2)
Mammary gland carcinosarcoma None (spontaneous) (6)
Mammary gland tumor None (spontaneous) (32)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (2)
Mesodermal cell/mesoblast sarcoma Hormone (2)
Mesodermal cell/mesoblast sarcoma Genetic Modification (6)
Mesodermal cell/mesoblast sarcoma - spindle cell None (spontaneous) (5)
Mesodermal cell/mesoblast sarcoma - spindle cell Genetic Modification (2)
Mesothelium mesothelioma - malignant Genetic Modification (6)
Mesothelium mesothelioma - malignant - biphasic Genetic Modification (8)
Mesothelium mesothelioma - malignant - epithelial Genetic Modification (7)
Mesothelium mesothelioma - malignant - sarcomatoid Genetic Modification (12)
Muscle - Smooth leiomyoma Genetic Modification (5)
Muscle - Smooth leiomyosarcoma Hormone (3)
Muscle - Smooth leiomyosarcoma Genetic Modification (8)
Muscle - Striated - Skeletal rhabdomyosarcoma Genetic Modification (5)
Muscle - Striated - Skeletal rhabdomyosarcoma - alveolar None (spontaneous) (2)
Muscle - Striated - Skeletal rhabdomyosarcoma - alveolar Genetic Modification (3)
Muscle - Striated - Skeletal rhabdomyosarcoma - embryonal None (spontaneous) (7)
Muscle - Striated - Skeletal rhabdomyosarcoma - embryonal Genetic Modification (3)
Muscle - Striated - Skeletal rhabdomyosarcoma - pleomorphic None (spontaneous) (1)
Muscle - Striated - Skeletal rhabdomyosarcoma - pleomorphic Genetic Modification (1)
Ovary dysplasia Genetic Modification (1)
Ovary - Germ cell teratocarcinoma Hormone (1)
Ovary - Germ cell teratocarcinoma Genetic Modification (1)
Ovary tumor Genetic Modification (1)
Pancreas adenocarcinoma - ductal None (spontaneous) (3)
Pancreas adenocarcinoma - ductal Chemical/Drug (1)
Pancreas - Duct pancreatic intraepithelial neoplasia (PanIN) None (spontaneous) (1)
Pituitary gland adenoma None (spontaneous) (2)
Pituitary gland adenoma Genetic Modification (2)
PNS - Schwann cell schwannoma Genetic Modification (5)
Prostate gland carcinoma None (spontaneous) (1)
Salivary gland tumor None (spontaneous) (4)
Skin carcinoma None (spontaneous) (2)
Skin - Melanocyte melanoma - amelanotic Genetic Modification (1)
Skin pilomatrixoma None (spontaneous) (2)
Skin squamous cell carcinoma None (spontaneous) (4)
Skin squamous cell carcinoma Chemical/Drug (2)
Skin tumor None (spontaneous) (6)
Skin tumor Chemical/Drug (4)
Thoracic cavity tumor Genetic Modification (5)
Thymus thymoma None (spontaneous) (4)
Thyroid gland - Medulla - C cell carcinoma Genetic Modification (1)
Uterus adenocarcinoma Hormone (1)
Uterus adenocarcinoma Genetic Modification (1)
Uterus - Cervix cervical intraepithelial neoplasia - grade 3 (CIN3) Hormone (1)
Uterus - Endometrium - Stroma tumor Hormone (1)
Uterus - Endometrium - Stroma tumor Genetic Modification (1)
Uterus - Endometrium tumor None (spontaneous) (4)
(Unspecified organ) neoplasm None (spontaneous) (1)
(Unspecified organ) tumor None (spontaneous) (33)
(Unspecified organ) tumor Hormone (4)
(Unspecified organ) tumor Genetic Modification (16)
Trp53tm1Brd
targeted mutation 1, Allan Bradley
Bone osteosarcoma None (spontaneous) (4)
CNS - Brain - Oligodendroglial cell oligodendroglioma None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (1)
Intestine - Large Intestine adenoma Chemical/Drug (2)
Intestine - Large Intestine atypia Chemical/Drug (1)
Intestine - Large Intestine carcinoma Chemical/Drug (1)
Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - Pro-B-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - T-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - T-lymphocyte lymphoma Radiation (1)
Leukocyte lymphoma None (spontaneous) (6)
Leukocyte lymphoma Chemical/Drug (4)
Liver - Bile duct cholangiocarcinoma None (spontaneous) (1)
Liver hepatocellular carcinoma Chemical/Drug (1)
Liver tumor Chemical/Drug (4)
Mammary gland adenocarcinoma None (spontaneous) (3)
Mammary gland carcinoma None (spontaneous) (3)
Mammary gland tumor None (spontaneous) (4)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (3)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
Muscle sarcoma - unclassified None (spontaneous) (1)
Muscle - Striated - Skeletal rhabdomyosarcoma None (spontaneous) (3)
Myoepithelial cell myoepithelioma None (spontaneous) (1)
Pancreas - Acinar cell carcinoma - acinar Chemical/Drug (1)
Pancreas - Islet of Langerhans carcinoma None (spontaneous) (1)
Salivary gland tumor None (spontaneous) (1)
Thyroid gland - Medulla carcinoma None (spontaneous) (1)
Urinary bladder dysplasia Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (3)
Urinary bladder transitional cell carcinoma Chemical/Drug (2)
Urinary bladder - Transitional cell carcinoma Chemical/Drug (1)
Urinary bladder tumor Chemical/Drug (1)
(Unspecified organ) tumor None (spontaneous) (16)
(Unspecified organ) tumor Chemical/Drug (1)
Trp53tm1Mlh
targeted mutation 1, Martin L Hooper
Leukocyte - Lymphocyte lymphoma None (spontaneous) (2)
Leukocyte - Lymphocyte - Thymocyte lymphoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (2)
Pancreas - Acinar cell adenocarcinoma None (spontaneous) (1)
Pancreas preneoplastic lesion None (spontaneous) (1)
Trp53tm1Sia
targeted mutation 1, Shinichi Aizawa
Adipose tissue lipoma None (spontaneous) (1)
Blood vessel hemangiosarcoma None (spontaneous) (2)
Leukocyte lymphoma None (spontaneous) (3)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (1)
Trp53tm1Tyj
targeted mutation 1, Tyler Jacks
Blood vessel hemangiosarcoma None (spontaneous) (2)
Bone osteosarcoma None (spontaneous) (9)
Bone osteosarcoma - anaplastic None (spontaneous) (1)
Bone tumor None (spontaneous) (1)
CNS - Brain - Astrocyte astrocytoma None (spontaneous) (3)
CNS - Brain - Astrocyte astrocytoma - malignant None (spontaneous) (1)
CNS - Brain - Choroid plexus tumor None (spontaneous) (2)
CNS - Brain glioblastoma None (spontaneous) (1)
CNS - Brain medulloblastoma None (spontaneous) (2)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (2)
Ear - Outer ear - Ear canal squamous cell carcinoma None (spontaneous) (4)
Ear squamous cell carcinoma None (spontaneous) (2)
Intestine - Small Intestine adenoma None (spontaneous) (1)
Leukocyte - Lymphocyte - Immature T-lymphocyte lymphoma Genetic Modification (2)
Leukocyte - Lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma - lymphoblastic Virus (1)
Leukocyte - Lymphocyte - Thymocyte lymphoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (4)
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma None (spontaneous) (2)
Leukocyte - Myelocyte (Granulocyte) hyperplasia Genetic Modification (2)
Leukocyte - Myelocyte (Granulocyte) leukemia None (spontaneous) (1)
Liver hepatocellular carcinoma None (spontaneous) (1)
Lung adenocarcinoma None (spontaneous) (2)
Lung adenocarcinoma Genetic Modification (2)
Lung adenoma Genetic Modification (1)
Lung adenoma - cuboidal None (spontaneous) (1)
Lung lesion Genetic Modification (2)
Lymphoid tissue lymphoma None (spontaneous) (3)
Mammary gland adenocarcinoma None (spontaneous) (3)
Mammary gland carcinoma None (spontaneous) (2)
Mammary gland tumor None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (4)
Mesodermal cell/mesoblast sarcoma - anaplastic None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma - spindle cell Genetic Modification (1)
Mesodermal cell/mesoblast sarcoma - unclassified None (spontaneous) (1)
Muscle - Smooth leiomyosarcoma None (spontaneous) (1)
Muscle - Striated - Skeletal rhabdomyosarcoma None (spontaneous) (3)
Oral cavity papilloma Genetic Modification (2)
Pancreas - Acinar cell carcinoma None (spontaneous) (1)
Pancreas adenocarcinoma None (spontaneous) (1)
Pancreas carcinoma None (spontaneous) (2)
Pancreas cystadenoma - serous None (spontaneous) (2)
Pancreas - Islet of Langerhans tumor None (spontaneous) (1)
Pancreas tumor None (spontaneous) (1)
Pineal gland pineoblastoma None (spontaneous) (1)
PNS - Ganglion - Dorsal root tumor None (spontaneous) (1)
PNS - Nerve sheath tumor - malignant None (spontaneous) (2)
PNS - Nerve tumor None (spontaneous) (2)
PNS - Schwann cell neurofibrosarcoma None (spontaneous) (1)
Skin - Melanocyte melanoma None (spontaneous) (1)
Urinary bladder transitional cell carcinoma None (spontaneous) (1)
Uterus adenocarcinoma None (spontaneous) (1)
(Unspecified organ) adenocarcinoma None (spontaneous) (1)
(Unspecified organ) carcinoma None (spontaneous) (2)
(Unspecified organ) squamous cell carcinoma None (spontaneous) (3)
(Unspecified organ) tumor None (spontaneous) (15)
Trp53tm3.1Tyj-sm
targeted mutation 3.1 (somatic), Tyler Jacks
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma Chemical/Drug (1)
Lung adenocarcinoma Genetic Modification (1)
Lung tumor Genetic Modification (1)
Mammary gland adenocarcinoma None (spontaneous) (1)
Mammary gland adenocarcinoma Chemical/Drug (1)
Mammary gland carcinoma None (spontaneous) (1)
Mammary gland carcinoma Chemical/Drug (1)
Mammary gland carcinoma - adenosquamous None (spontaneous) (1)
Mammary gland carcinoma - adenosquamous Chemical/Drug (1)
Mammary gland carcinoma - papillary None (spontaneous) (1)
Mammary gland carcinoma - papillary Chemical/Drug (1)
Mammary gland carcinoma - solid None (spontaneous) (1)
Mammary gland carcinoma - solid Chemical/Drug (1)
Mammary gland carcinosarcoma None (spontaneous) (1)
Mammary gland carcinosarcoma Chemical/Drug (1)
Mammary gland hyperplasia None (spontaneous) (1)
Mammary gland hyperplasia Chemical/Drug (2)
Mammary gland mammary intraepithelial neoplasia (MIN) None (spontaneous) (1)
Mammary gland mammary intraepithelial neoplasia (MIN) Chemical/Drug (1)
Mammary gland tumor None (spontaneous) (1)
Mammary gland tumor Chemical/Drug (1)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (2)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
(Unspecified organ) tumor None (spontaneous) (1)