Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Smad4
Gene Name SMAD family member 4
Mouse Chromosome 18
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Smad4tm1Cxd
targeted mutation 1, Chu-Xia Deng
Stomach - Glandular - Pyloric antrum carcinoma None (spontaneous) (1)
Stomach - Glandular - Pyloric antrum tumor None (spontaneous) (1)
Smad4tm1Mmt
targeted mutation 1, Makoto M Taketo
Intestine - Small Intestine adenoma None (spontaneous) (1)
Intestine - Small Intestine - Duodenum polyp None (spontaneous) (1)
Stomach - Glandular polyp None (spontaneous) (1)
Smad4tm2.2sCxd-sm
targeted mutation 2.2 (somatic), Chu-Xia Deng
Skin - Dorsal region carcinoma - spindle cell Chemical/Drug (1)
Skin - Dorsal region dysplasia - squamous Chemical/Drug (1)
Skin - Dorsal region papilloma Chemical/Drug (1)
Skin - Dorsal region squamous cell carcinoma Chemical/Drug (5)
Skin - Dorsal region squamous cell carcinoma - moderately differentiated Chemical/Drug (1)
Skin - Dorsal region squamous cell carcinoma - well differentiated Chemical/Drug (1)
Skin - Dorsal region tumor Chemical/Drug (4)
Skin - Dorsal region tumor - epidermoid Chemical/Drug (1)
Skin gland - Sebaceous gland adenoma - sebaceous Chemical/Drug (1)
Skin - Hair follicle - Basal cell carcinoma Chemical/Drug (1)
Skin - Hair follicle - Basal cell squamous cell carcinoma Chemical/Drug (2)
Skin - Hair follicle - Basal cell trichoepithelioma Chemical/Drug (1)