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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Cdkn2a
Gene Name cyclin dependent kinase inhibitor 2A
Mouse Chromosome 4
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Cdkn2atm1.1Brn
targeted mutation 1.1, Anton Berns
Leukocyte lymphoma Genetic Modification (3)
Leukocyte - Monocyte leukemia - myelocytic Genetic Modification (2)
Liver - Bile duct cholangiocarcinoma Genetic Modification (2)
Liver hepatoma Genetic Modification (2)
Liver - Oval cell hyperplasia Genetic Modification (2)
Lung adenocarcinoma None (spontaneous) (1)
Mesothelium mesothelioma - malignant Genetic Modification (1)
Mesothelium mesothelioma - malignant - biphasic Genetic Modification (3)
Mesothelium mesothelioma - malignant - epithelial Genetic Modification (2)
Mesothelium mesothelioma - malignant - sarcomatoid Genetic Modification (2)
Muscle - Smooth leiomyoma Genetic Modification (2)
Muscle - Striated - Skeletal rhabdomyosarcoma Genetic Modification (2)
PNS - Schwann cell schwannoma Genetic Modification (2)
Skin carcinoma None (spontaneous) (1)
Skin - Melanocyte melanoma None (spontaneous) (1)
Thoracic cavity tumor Genetic Modification (2)
Uterus carcinoma None (spontaneous) (1)
(Unspecified organ) angiosarcoma None (spontaneous) (1)
(Unspecified organ) tumor Genetic Modification (1)
Cdkn2atm1Cjs
targeted mutation 1, Charles J Scherr
Pancreas - Islet of Langerhans tumor None (spontaneous) (1)
Pituitary gland - Pars intermedia tumor None (spontaneous) (1)
(Unspecified organ) tumor None (spontaneous) (2)
Cdkn2atm1Rdp
targeted mutation 1, Ronald DePinho
Adrenal gland - Medulla pheochromocytoma None (spontaneous) (1)
CNS - Brain - Oligodendroglial cell oligodendroglioma None (spontaneous) (1)
Lung adenocarcinoma Chemical/Drug (2)
Muscle - Striated - Skeletal rhabdomyosarcoma None (spontaneous) (1)
Pancreas cystadenoma - serous None (spontaneous) (3)
Skin - Melanocyte melanoma None (spontaneous) (1)
Cdkn2atm2.1Brn-sm
targeted mutation 2.1 (somatic), Anton Berns
Leukocyte lymphoma Genetic Modification (3)
Leukocyte - Monocyte leukemia - myelocytic Genetic Modification (3)
Liver - Bile duct cholangiocarcinoma Genetic Modification (3)
Liver hepatoma Genetic Modification (3)
Liver - Oval cell hyperplasia Genetic Modification (3)
Mesothelium mesothelioma - malignant Genetic Modification (4)
Mesothelium mesothelioma - malignant - biphasic Genetic Modification (4)
Mesothelium mesothelioma - malignant - epithelial Genetic Modification (3)
Mesothelium mesothelioma - malignant - sarcomatoid Genetic Modification (7)
Muscle - Smooth leiomyoma Genetic Modification (3)
Muscle - Smooth leiomyosarcoma Genetic Modification (1)
Muscle - Striated - Skeletal rhabdomyosarcoma Genetic Modification (3)
PNS - Schwann cell schwannoma Genetic Modification (3)
Thoracic cavity tumor Genetic Modification (3)
(Unspecified organ) tumor Genetic Modification (3)
Cdkn2atm2.1Brn
targeted mutation 2.1, Anton Berns
Lung adenocarcinoma None (spontaneous) (1)
Skin carcinoma None (spontaneous) (1)
Skin - Melanocyte melanoma None (spontaneous) (1)
Uterus carcinoma None (spontaneous) (1)
(Unspecified organ) angiosarcoma None (spontaneous) (1)
Cdkn2atm2.2Nesh-sm
targeted mutation 2.2 (somatic), Norman E Sharpless
Skin - Melanocyte melanoma - amelanotic Genetic Modification (1)
Cdkn2atm4.1Rdp-sm
targeted mutation 4.1 (somatic), Ronald DePinho
Pancreas adenocarcinoma - ductal None (spontaneous) (1)