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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Brca1
Gene Name breast cancer 1, early onset
Mouse Chromosome 11
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Brca1tm1.1Brn-sm
targeted mutation 1.1 (somatic), Anton Berns
Mammary gland carcinoma None (spontaneous) (1)
Mammary gland carcinoma - poorly differentiated None (spontaneous) (1)
Mammary gland carcinoma - well-differentiated None (spontaneous) (1)
Mammary gland tumor None (spontaneous) (8)
Mesodermal cell/mesoblast sarcoma Hormone (2)
Mesodermal cell/mesoblast sarcoma Genetic Modification (2)
Muscle - Smooth leiomyosarcoma Hormone (1)
Muscle - Smooth leiomyosarcoma Genetic Modification (3)
Ovary - Germ cell teratocarcinoma Hormone (1)
Ovary - Germ cell teratocarcinoma Genetic Modification (1)
Skin tumor None (spontaneous) (4)
Uterus adenocarcinoma Hormone (1)
Uterus adenocarcinoma Genetic Modification (1)
Uterus - Endometrium - Stroma tumor Hormone (1)
Uterus - Endometrium - Stroma tumor Genetic Modification (1)
(Unspecified organ) tumor None (spontaneous) (8)
(Unspecified organ) tumor Hormone (4)
(Unspecified organ) tumor Genetic Modification (4)
Brca1tm1Bhk
targeted mutation 1, Beverly H Koller
Blood vessel hemangiosarcoma Radiation (1)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (1)
Germ cell (sex not specified) teratoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (2)
Mammary gland carcinoma None (spontaneous) (1)
Mammary gland carcinoma Radiation (1)
Mammary gland tumor None (spontaneous) (2)
Ovary tumor Radiation (1)
Rete ovarii adenocarcinoma None (spontaneous) (1)
Skin - Epidermis - Basal cell carcinoma None (spontaneous) (1)
Skin pilomatrixoma Radiation (1)
(Unspecified organ) carcinoma None (spontaneous) (1)
(Unspecified organ) histiocytoma - fibrous Radiation (1)
(Unspecified organ) reticulum cell sarcoma None (spontaneous) (1)
Brca1tm1Cxd
targeted mutation 1, Chu-Xia Deng
Mammary gland adenocarcinoma None (spontaneous) (2)
Mammary gland hyperplasia None (spontaneous) (2)
Mammary gland tumor None (spontaneous) (1)
Brca1tm2.1Cxd-sm
targeted mutation 2.1 (somatic), Chu-Xia Deng
Mammary gland adenocarcinoma None (spontaneous) (2)
Mammary gland hyperplasia None (spontaneous) (2)
Mammary gland tumor None (spontaneous) (1)