Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Nf2
Gene Name neurofibromin 2
Mouse Chromosome 11
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Nf2tm1Gth
targeted mutation 1, Gilles Thomas
Bone osteosarcoma None (spontaneous) (2)
Kidney carcinoma - anaplastic None (spontaneous) (1)
Lung adenocarcinoma None (spontaneous) (1)
Mammary gland carcinosarcoma None (spontaneous) (1)
Mammary gland fibroadenoma None (spontaneous) (1)
Mesothelium mesothelioma None (spontaneous) (1)
PNS - Schwann cell schwannoma - malignant None (spontaneous) (1)
Nf2tm1Tyj
targeted mutation 1, Tyler Jacks
Bone osteosarcoma None (spontaneous) (9)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (5)
Leukocyte lymphoma None (spontaneous) (4)
Liver hepatocellular adenoma None (spontaneous) (5)
Liver hepatocellular carcinoma None (spontaneous) (3)
Lung adenocarcinoma None (spontaneous) (4)
Mesothelium mesothelioma - malignant Chemical/Drug (2)
Nf2tm2.1Gth
targeted mutation 2.1, Gilles Thomas
Bone osteosarcoma None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (1)
Mammary gland fibroadenoma None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma - stromal None (spontaneous) (1)
PNS - Schwann cell neurofibrosarcoma None (spontaneous) (1)
PNS - Schwann cell schwannoma None (spontaneous) (1)
PNS - Schwann cell schwannoma - malignant None (spontaneous) (2)