Mouse Tumor Biology Database (MTB)
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Last Database Update
MTB 3.0
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Nf1
Gene Name neurofibromin 1
Mouse Chromosome 11
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
targeted mutation 1.1 (somatic), Luis F Parada
CNS - Brain - Astrocyte astrocytoma - malignant None (spontaneous) (1)
PNS - Ganglion ganglioneuroma None (spontaneous) (3)
PNS - Schwann cell hyperplasia None (spontaneous) (1)
PNS - Schwann cell neurofibroma - plexiform None (spontaneous) (1)
targeted mutation 1, Fredrick Cancer Research and Development Center
Leukocyte lymphoma None (spontaneous) (2)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (1)
PNS - Schwann cell neurofibroma - plexiform None (spontaneous) (1)
targeted mutation 1, Tyler Jacks
Adrenal gland - Medulla pheochromocytoma None (spontaneous) (1)
Bone osteosarcoma Radiation (1)
CNS - Brain - Astrocyte astrocytoma None (spontaneous) (3)
CNS - Brain glioblastoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (1)
Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic None (spontaneous) (1)
Lung adenocarcinoma None (spontaneous) (1)
PNS - Schwann cell neurofibroma - plexiform None (spontaneous) (1)
PNS - Schwann cell neurofibrosarcoma None (spontaneous) (1)
targeted mutation 2, Tyler Jacks
PNS - Schwann cell neurofibroma - plexiform None (spontaneous) (1)