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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Pten
Gene Name phosphatase and tensin homolog
Mouse Chromosome 19
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Ptentm1.1Gle
targeted mutation 1.1, Gustavo Leone
Prostate gland lesion - proliferative None (spontaneous) (1)
Thyroid gland - Follicular cell lesion - proliferative None (spontaneous) (1)
Uterus - Endometrium lesion - proliferative None (spontaneous) (1)
Ptentm1.1Hwu-sm
targeted mutation 1.1 (somatic), Hong Wu
Intestine adenocarcinoma - mucinous None (spontaneous) (1)
Intestine - Large Intestine - Colon hyperplasia Genetic Modification (1)
Intestine - Large Intestine - Colon tumor Genetic Modification (1)
Intestine - Small Intestine polyp - hamartomatous Genetic Modification (2)
Leukocyte hyperplasia None (spontaneous) (1)
Leukocyte leukemia None (spontaneous) (2)
Leukocyte - Lymphocyte - T-lymphocyte hyperplasia None (spontaneous) (2)
Leukocyte - Lymphocyte - T-lymphocyte leukemia - lymphoblastic None (spontaneous) (3)
Leukocyte - Myelocyte (Granulocyte) leukemia - acute myeloid (AML) None (spontaneous) (1)
Mammary gland tumor None (spontaneous) (3)
Ovary carcinoma - endometrioid Genetic Modification (1)
Prostate gland hyperplasia Genetic Modification (1)
Prostate gland hyperplasia - epithelial None (spontaneous) (1)
Prostate gland lesion None (spontaneous) (1)
Prostate gland prostatic intraepithelial neoplasia - high grade (HGPIN) None (spontaneous) (1)
Prostate gland prostatic intraepithelial neoplasia - low grade (LGPIN) None (spontaneous) (1)
Prostate gland prostatic intraepithelial neoplasia (PIN) None (spontaneous) (1)
Prostate gland tumor None (spontaneous) (2)
Prostate gland tumor Genetic Modification (1)
Thyroid gland - Medulla - C cell carcinoma Genetic Modification (1)
Ptentm1.1Mro-sm
targeted mutation 1.1 (somatic), Silvia Marino
Prostate gland adenocarcinoma None (spontaneous) (1)
Prostate gland carcinoma - invasive None (spontaneous) (1)
Prostate gland hyperplasia None (spontaneous) (7)
Prostate gland prostatic intraepithelial neoplasia (PIN) None (spontaneous) (3)
Ptentm1.2Mwst
targeted mutation 1.2, Michael Weinstein
Mammary gland adenocarcinoma None (spontaneous) (1)
Prostate gland lesion - proliferative None (spontaneous) (1)
Thyroid gland - Follicular cell lesion - proliferative None (spontaneous) (1)
Uterus - Endometrium lesion - proliferative None (spontaneous) (1)
Ptentm1Mak
targeted mutation 1, Tak W Mak
Leukocyte - Lymphocyte - T-lymphocyte thymoma None (spontaneous) (1)
Leukocyte - Lymphocyte - T-lymphocyte thymoma Radiation (1)
Leukocyte lymphoma None (spontaneous) (1)
Mammary gland tumor None (spontaneous) (1)
Prostate gland adenocarcinoma None (spontaneous) (1)
Uterus carcinoma None (spontaneous) (1)
Ptentm1Ppp
targeted mutation 1, Pier Paolo Pandolfi
Adrenal gland tumor None (spontaneous) (3)
Intestine - Large Intestine - Colon adenocarcinoma - well-differentiated None (spontaneous) (1)
Intestine - Large Intestine hyperplasia - glandular None (spontaneous) (1)
Intestine - Large Intestine polyp None (spontaneous) (1)
Leukocyte lymphoma Radiation (2)
Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic None (spontaneous) (1)
Lung tumor None (spontaneous) (2)
Mammary gland tumor None (spontaneous) (2)
Pituitary gland tumor None (spontaneous) (2)
Prostate gland hyperplasia None (spontaneous) (1)
Prostate gland tumor None (spontaneous) (3)
Skin - Epidermis hyperplasia None (spontaneous) (1)
Testis - Germ cell teratocarcinoma None (spontaneous) (1)
Testis - Leydig cell (Interstitial cell) tumor None (spontaneous) (1)
Thyroid gland adenocarcinoma - papillary None (spontaneous) (1)
Thyroid gland tumor None (spontaneous) (2)
Uterus tumor None (spontaneous) (1)
Ptentm1Rps
targeted mutation 1, Ramon Parsons
Adrenal gland - Medulla pheochromocytoma None (spontaneous) (2)
Leukocyte - Lymphoblast lymphoma None (spontaneous) (1)
Mammary gland adenocarcinoma None (spontaneous) (1)
Prostate gland carcinoma None (spontaneous) (1)
Ptentm2.1Gle
targeted mutation 2.1, Gustavo Leone
Mammary gland adenocarcinoma None (spontaneous) (1)
Prostate gland lesion - proliferative None (spontaneous) (1)
Thyroid gland - Follicular cell lesion - proliferative None (spontaneous) (1)
Uterus - Endometrium lesion - proliferative None (spontaneous) (1)
Ptentm2.1Mak-sm
targeted mutation 2.1 (somatic), Tak W Mak
CNS - Brain - Choroid plexus carcinoma Genetic Modification (2)
CNS - Brain - Choroid plexus tumor Genetic Modification (1)
CNS - Brain tumor Genetic Modification (1)
Leukocyte - Lymphocyte - T-lymphocyte lymphoma None (spontaneous) (7)
Skin - Epidermis carcinoma None (spontaneous) (1)
Skin - Epidermis hyperplasia None (spontaneous) (1)
Skin - Epidermis tumor None (spontaneous) (1)
Skin gland - Sebaceous gland carcinoma None (spontaneous) (1)
Skin gland - Sweat gland adenocarcinoma None (spontaneous) (1)
Skin papilloma Chemical/Drug (1)
Ptentm2.2Ppp-sm
targeted mutation 2.2 (somatic), Pier Paolo Pandolfi
Thyroid gland carcinoma - follicular None (spontaneous) (1)