Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search for Help
 
in these sections
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets

Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology

Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice

Send Questions and
Comments to User Support.

Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Apc
Gene Name APC, WNT signaling pathway regulator
Mouse Chromosome 18
Genetic Change Type Targeted mutation (knockout)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Apctm1.1Rsmi
targeted mutation 1.1, Ron Smits
Intestine tumor None (spontaneous) (1)
Apctm1.1Tno-sm
targeted mutation 1.1 (somatic), Tetsuo Noda
Intestine - Large Intestine adenocarcinoma Genetic Modification (1)
Intestine - Large Intestine adenoma Genetic Modification (2)
Mammary gland metaplasia None (spontaneous) (1)
Apctm1Cip-sm
targeted mutation 1 (somatic), Christine Perret
Intestine dysplasia Genetic Modification (1)
Intestine lesion Genetic Modification (1)
Intestine - Small Intestine adenocarcinoma Genetic Modification (1)
Intestine - Small Intestine dysplasia Genetic Modification (1)
Liver foci - preneoplastic Genetic Modification (1)
Liver hepatocellular carcinoma Genetic Modification (2)
Liver hepatocellular carcinoma - moderately differentiated Genetic Modification (1)
Liver hepatocellular carcinoma - poorly differentiated Genetic Modification (1)
Liver hepatocellular carcinoma - well-differentiated Genetic Modification (1)
Liver - Hepatocyte hyperplasia Genetic Modification (2)
Liver tumor Genetic Modification (2)
Apctm1Cip
targeted mutation 1, Christine Perret
Intestine - Large Intestine - Colon polyp None (spontaneous) (1)
Intestine - Large Intestine - Colon polyp Not Specified (1)
Intestine - Small Intestine polyp None (spontaneous) (1)
Intestine - Small Intestine polyp Not Specified (1)
Apctm1Mmt
targeted mutation 1, Makoto M Taketo
Intestine adenoma None (spontaneous) (2)
Intestine - Large Intestine adenoma None (spontaneous) (2)
Intestine - Large Intestine - Colon adenoma None (spontaneous) (2)
Intestine polyp - adenomatous None (spontaneous) (1)
Intestine - Small Intestine adenoma None (spontaneous) (4)
Intestine - Small Intestine - Ileum adenoma None (spontaneous) (1)
Intestine - Small Intestine polyp None (spontaneous) (1)
Apctm1Rak
targeted mutation 1, Raju Kucherlapati
Connective tissue - Fibroblast desmoid None (spontaneous) (4)
Gastrointestinal tract tumor None (spontaneous) (11)
Intestine adenocarcinoma None (spontaneous) (1)
Intestine - Large Intestine - Colon - Proximal foci - aberrant crypt (ACF) Not Specified (1)
Intestine - Small Intestine tumor Not Specified (1)
Intestine - Small Intestine tumor None (spontaneous) (1)
Intestine tumor Radiation (3)
Intestine tumor None (spontaneous) (3)
Mammary gland carcinoma - adenosquamous None (spontaneous) (2)
Mammary gland carcinoma - adenosquamous Radiation (3)
Ovary - Sex cord stromal cell tumor Radiation (1)
Skin gland - Sebaceous gland cyst None (spontaneous) (2)
Apctm2.1Rak-sm
targeted mutation 2.1 (somatic), Raju Kucherlapati
Intestine - Large Intestine - Colon - Distal adenocarcinoma Genetic Modification (1)
Intestine - Large Intestine - Colon - Distal adenoma Genetic Modification (2)
Intestine - Large Intestine - Colon - Distal tumor Chemical/Drug (2)
Intestine - Large Intestine - Colon - Distal tumor Genetic Modification (4)
Mammary gland tumor None (spontaneous) (6)
Mammary gland tumor - acinar None (spontaneous) (1)
Mammary gland tumor - basosquamous None (spontaneous) (1)
Mammary gland tumor - pilar None (spontaneous) (1)
Mammary gland tumor - undifferentiated None (spontaneous) (1)
Apctm2.1Rak
targeted mutation 2.1, Raju Kucherlapati
Mammary gland tumor None (spontaneous) (1)
Mammary gland tumor - pilar None (spontaneous) (1)