Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Trp53
Gene Name transformation related protein 53
Mouse Chromosome 11
Genetic Change Type Targeted mutation (knock-in)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Trp53tm1Glo
targeted mutation 1, Guillermina Lozano
Bone osteosarcoma None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (1)
Liver hepatocellular carcinoma None (spontaneous) (1)
Lung adenocarcinoma None (spontaneous) (2)
Skin squamous cell carcinoma Chemical/Drug (1)
Skin tumor Chemical/Drug (1)
(Unspecified organ) adenocarcinoma None (spontaneous) (1)
(Unspecified organ) angiosarcoma Genetic Modification (1)
Trp53tm1Wahl
targeted mutation 1, Geoffrey M Wahl
Adipose tissue liposarcoma None (spontaneous) (1)
Bone osteosarcoma None (spontaneous) (1)
CNS - Brain - Choroid plexus tumor None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (2)
Skin squamous cell carcinoma None (spontaneous) (1)
(Unspecified organ) angiosarcoma None (spontaneous) (1)
(Unspecified organ) tumor None (spontaneous) (1)
Trp53tm2.1Tyj-sm
targeted mutation 2.1 (somatic), Tyler Jacks
Pancreas adenocarcinoma - ductal None (spontaneous) (7)
Pancreas adenocarcinoma - ductal Chemical/Drug (5)
Pancreas - Duct pancreatic intraepithelial neoplasia (PanIN) None (spontaneous) (3)
Trp53tm2.1Tyj
targeted mutation 2.1, Tyler Jacks
Blood vessel hemangiosarcoma None (spontaneous) (1)
Muscle - Smooth leiomyosarcoma None (spontaneous) (1)
(Unspecified organ) tumor None (spontaneous) (7)
Trp53tm3.1Glo
targeted mutation 3.1, Guillermina Lozano
(Unspecified organ) angiosarcoma Genetic Modification (2)
(Unspecified organ) tumor None (spontaneous) (3)
Trp53tm3.1Tyj
targeted mutation 3.1, Tyler Jacks
(Unspecified organ) tumor None (spontaneous) (1)