Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Kras
Gene Name Kirsten rat sarcoma viral oncogene homolog
Mouse Chromosome 6
Genetic Change Type Targeted mutation (knock-in)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Krastm4.1Bbd
targeted mutation 4.1, Mariano Barbacid
Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
Lung adenoma None (spontaneous) (1)
Krastm4.1Tyj-sm
targeted mutation 4.1 (somatic), Tyler Jacks
Lung adenocarcinoma Genetic Modification (24)
Lung adenoma Genetic Modification (4)
Lung adenoma - papillary Genetic Modification (3)
Lung - Alveolus - Type II cell tumor Genetic Modification (1)
Lung - Bronchiole dysplasia Genetic Modification (3)
Lung - Bronchiole - Epithelium adenocarcinoma Chemical/Drug (6)
Lung - Bronchiole - Epithelium adenocarcinoma Genetic Modification (14)
Lung - Bronchiole hyperplasia Genetic Modification (3)
Lung carcinoma Genetic Modification (1)
Lung carcinoma - adenosquamous Genetic Modification (7)
Lung carcinoma - large cell (LCC) Genetic Modification (2)
Lung - Club cell tumor Genetic Modification (1)
Lung hyperplasia Genetic Modification (4)
Lung squamous cell carcinoma Genetic Modification (7)
Lung tumor Genetic Modification (15)
Oral cavity squamous cell papilloma Genetic Modification (1)
Pancreas adenocarcinoma - ductal None (spontaneous) (13)
Pancreas adenocarcinoma - ductal Chemical/Drug (6)
Pancreas - Duct pancreatic intraepithelial neoplasia (PanIN) None (spontaneous) (8)
Skin - Dorsal region carcinoma - spindle cell Chemical/Drug (1)
Skin - Dorsal region dysplasia - squamous Chemical/Drug (1)
Skin - Dorsal region papilloma Chemical/Drug (3)
Skin - Dorsal region squamous cell carcinoma Chemical/Drug (5)
Skin - Dorsal region squamous cell carcinoma - moderately differentiated Chemical/Drug (1)
Skin - Dorsal region squamous cell carcinoma - well differentiated Chemical/Drug (1)
Skin - Dorsal region tumor Chemical/Drug (4)
Skin - Dorsal region tumor - epidermoid Chemical/Drug (1)
Skin - Dorsal region tumor - malignant Chemical/Drug (1)
Skin gland - Sebaceous gland adenoma - sebaceous Chemical/Drug (1)
Skin - Hair follicle - Basal cell carcinoma Chemical/Drug (1)
Skin - Hair follicle - Basal cell squamous cell carcinoma Chemical/Drug (2)
Skin - Hair follicle - Basal cell trichoepithelioma Chemical/Drug (1)
Skin - Melanocyte melanoma - amelanotic Genetic Modification (1)
Skin squamous cell carcinoma Chemical/Drug (3)
Skin tumor Chemical/Drug (7)
Thyroid gland carcinoma - follicular None (spontaneous) (1)