Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Nf2
Gene Name neurofibromin 2
Mouse Chromosome 11
Genetic Change Type Targeted mutation (conditional)

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Nf2tm2.1Gth-sm
targeted mutation 2.1 (somatic), Gilles Thomas
Bone osteosarcoma None (spontaneous) (1)
Bone tumor None (spontaneous) (1)
Leukocyte lymphoma Genetic Modification (7)
Leukocyte - Monocyte leukemia - myelocytic Genetic Modification (8)
Liver - Bile duct cholangiocarcinoma Genetic Modification (8)
Liver hepatoma Genetic Modification (8)
Liver - Oval cell hyperplasia Genetic Modification (8)
Mesodermal cell/mesoblast sarcoma - undifferentiated None (spontaneous) (1)
Mesothelium mesothelioma - malignant Genetic Modification (9)
Mesothelium mesothelioma - malignant - biphasic Genetic Modification (12)
Mesothelium mesothelioma - malignant - epithelial Genetic Modification (9)
Mesothelium mesothelioma - malignant - sarcomatoid Genetic Modification (19)
Muscle - Smooth leiomyoma Genetic Modification (8)
Muscle - Smooth leiomyosarcoma None (spontaneous) (1)
Muscle - Striated - Skeletal rhabdomyosarcoma Genetic Modification (8)
PNS - Ganglion - Dorsal root tumor None (spontaneous) (1)
PNS - Nerve sheath tumor - malignant None (spontaneous) (3)
PNS - Nerve tumor None (spontaneous) (2)
PNS - Schwann cell schwannoma None (spontaneous) (1)
PNS - Schwann cell schwannoma Genetic Modification (8)
Thoracic cavity tumor Genetic Modification (7)
(Unspecified organ) tumor Genetic Modification (7)
(Unspecified organ) tumor None (spontaneous) (1)