Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Trp53
Gene Name transformation related protein 53
Mouse Chromosome 11
Genetic Change Type Point mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
codon 131; unspecified Urinary bladder squamous cell carcinoma Chemical/Drug (1)
codon 132; unspecified Forestomach squamous cell carcinoma - well differentiated Chemical/Drug (1)
Urinary bladder dysplasia Chemical/Drug (1)
codon 133; unspecified Urinary bladder carcinoma Chemical/Drug (1)
codon 135; unspecified Urinary bladder carcinoma Chemical/Drug (1)
codon 140; unspecified Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 148; unspecified Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 159; unspecified Renal pelvis carcinoma Chemical/Drug (1)
Renal pelvis transitional cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 163; Tyr to Phe Skin - Melanocyte melanoma None (spontaneous) (1)
codon 169; Met to Ile Skin - Melanocyte melanoma None (spontaneous) (1)
codon 170; Thr to Leu Skin - Melanocyte melanoma None (spontaneous) (1)
codon 176; unspecified Renal pelvis carcinoma in situ Chemical/Drug (1)
codon 180; unspecified Forestomach squamous cell carcinoma - well differentiated Chemical/Drug (1)
codon 189; unspecified Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 203; Pro to Ala Skin - Melanocyte melanoma None (spontaneous) (1)
codon 213; unspecified Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
codon 213, Val to Ala (Unspecified organ) tumor None (spontaneous) (1)
codon 217; unspecified Renal pelvis carcinoma Chemical/Drug (1)
Renal pelvis squamous cell carcinoma Chemical/Drug (1)
codon 229; unspecified Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 238; unspecified Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
codon 247; unspecified Forestomach squamous cell carcinoma - well differentiated Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 250; unspecified Urinary bladder transitional cell carcinoma Chemical/Drug (1)
codon 251; unspecified Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
codon 252; unspecified Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
intron 7 G:C -> T:A transversion Blood vessel hemangiosarcoma Chemical/Drug (1)
intron 7 GTA->GGA Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 1024 (codon 342), AAT->GAT; Asn to Asp Mammary gland tumor None (spontaneous) (1)
nucleotide 1064 (codon 355), GAG->GGG; Glu to Gly (Unspecified organ) tumor - malignant None (spontaneous) (2)
nucleotide 109 (codon 37), TCA->CCA; Ser to Pro Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (2)
nucleotide 242 (codon 81), GCC->GTC; Ala to Val Liver hepatocellular carcinoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (1)
(Unspecified organ) tumor - solid - malignant None (spontaneous) (1)
nucleotide 338 (codon 113), GGG->GTG; Gly to Val Forestomach squamous cell carcinoma Chemical/Drug (1)
nucleotide 370 (codon 124), TCT->CCT; Ser to Pro Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 377 (codon 126), CCC->CGC; Pro to Arg Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 386 (codon 129), AAG->ATG; Lys to Met Mammary gland adenocarcinoma - poorly differentiated None (spontaneous) (1)
nucleotide 388 (codon 130), CTA->TTA; Leu to Leu (silent) Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 404 (codon 135), GCG->GTG; Ala to Val Urinary bladder carcinoma Chemical/Drug (2)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 421 (codon 141), CAG->GAG; Gln to Glu Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 424 (codon 142), TTG->GTG; Leu to Val Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 442 (codon 148), CCT->TCT; Pro to Ser Urinary bladder carcinoma Chemical/Drug (2)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 443 (codon 148), CCT->CTT; Pro to Leu Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (2)
nucleotide 456 (codon 152), AGC->AGG; Ser to Arg Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 458 (codon 153), CGT->CTT; Arg to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 464 (codon 155), CGC->CCC; Arg to Pro Mammary gland tumor None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 464 (codon 155), CGC->CTC; Arg to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (2)
nucleotide 466 (codon 156), GCC->CCC; Ala to Pro Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 467 (codon 156), GCC->GTC; Ala to Val Mesodermal cell/mesoblast sarcoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (1)
(Unspecified organ) tumor - solid - malignant None (spontaneous) (1)
nucleotide 476 (codon 159), ATC->AAC, Ile to Asn Urinary bladder carcinoma Chemical/Drug (2)
nucleotide 476 (codon 159), ATC->ACC; Ile to Thr Urinary bladder carcinoma Chemical/Drug (2)
nucleotide 478 (codon 160), TAC->CAC; Tyr to His Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 492 (codon 164), CAG->CAC; Gln to His Lung adenoma Chemical/Drug (1)
nucleotide 494 (codon 165), CAC->CGC; His to Arg Mammary gland adenocarcinoma - solid None (spontaneous) (1)
nucleotide 508 (codon 170), GTC->ATC; Val to Ile Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 508 (codon 170), GTG->TTG; Val to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 509 (codon 170), GTG->GCG; Val to Ala Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 512 (codon 171), CGC->CAC; Arg to His Forestomach papilloma Chemical/Drug (1)
nucleotide 515 (codon 172), CGC->CAC; Arg to His Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 528 (codon 176), CAT->CAA; His to Gln Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 539 (codon 180), TCC->TTC; Ser to Phe Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 542 (codon 181), GAT->GGT; Asp to Gly Urinary bladder carcinoma Chemical/Drug (2)
nucleotide 558 (codon 186), GCT->GCC; Ala to Ala (silent) Urinary bladder carcinoma Chemical/Drug (2)
nucleotide 572 (codon 191), CTT->CCT; Leu to Pro Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 611 (codon 204), GAA->GGA; Glu to Gly Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 629 (codon 210), CGC->CTC; Arg to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 631 (codon 211), ATC->GTC; Ile to Val Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 635 (codon 212), AGC->ACC; Ser to Thr Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 637 (codon 213), GTG->TTG; Val to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 679 (codon 227), ACC->CCC; Thr to Pro Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 688 (codon 229), CGC->TGC; Arg to Cys Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 697 (codon 233), TAC->GAC; Tyr to Asp Urinary bladder squamous cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 701 (codon 234), ATG->AGG; Met to Arg Urinary bladder dysplasia Chemical/Drug (1)
nucleotide 702 (codon 234), ATG->ATA; Met to Ile Leukocyte - Lymphocyte - Thymocyte lymphoma None (spontaneous) (1)
nucleotide 707 (codon 236), GGC->GAC; Gly to Asp Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 709 (codon 237), AGC->GGC; Ser to Gly Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (1)
nucleotide 711 (codon 237), AGC->AGA; Ser to Arg Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 712 (codon 238), TCC->CCC; Ser to Pro Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 715 (codon 239), TGC->AGC; Cys to Ser Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 716 (codon 239), TGC->TTC; Cys to Phe Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 721 (codon 241), GGG->AGG; Gly to Arg Lung adenoma Chemical/Drug (1)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 721 (codon 241), GGG->TGG; Gly to Trp Mesodermal cell/mesoblast sarcoma Chemical/Drug (2)
nucleotide 722 (codon 241), GGG->GTG; Gly to Val Mesodermal cell/mesoblast sarcoma Chemical/Drug (2)
nucleotide 724 (codon 242), GGC->TGC; Gly to Cys Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 728 (codon 243), ATG->AAG; Met to Lys Urinary bladder carcinoma Chemical/Drug (2)
nucleotide 728 (codon 243), ATG->ACG; Met to Lys Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 734 (codon 245), CGC->CAC; Arg to His Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 734 (codon 245), CGC->CCC; Arg to Pro Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 737 (codon 246), CGA->CCA; Arg to Pro Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 737 (codon 246), CGA->CTA; Arg to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 739 (codon 247), CCT->TCT; Pro to Ser Lung adenoma Chemical/Drug (1)
nucleotide 749 (codon 250), ACC->ATC; Thr to Ile Intestine - Large Intestine carcinoma Chemical/Drug (1)
nucleotide 752 (codon 251), ATC->AGC; Ile to Ser Urinary bladder dysplasia Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 755 (codon 252), ATC->AAC; Ile to Asn Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 755 (codon 252), ATC->ACC; Ile to Thr Urinary bladder carcinoma Chemical/Drug (2)
Urinary bladder dysplasia Chemical/Drug (2)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
nucleotide 757 (codon 253), ACA->GCA; Thr to Ala Lung adenoma Chemical/Drug (1)
nucleotide 758 (codon 253), ACA->AAA; Thr to Lys Urinary bladder transitional cell carcinoma Chemical/Drug (2)
nucleotide 766 (codon 256), GAT->AAT; Asp to Asn Mammary gland adenocarcinoma None (spontaneous) (1)
nucleotide 771 (codon 257), TCC->TCT; Ser to Ser (silent) Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 773 (codon 258), AGT->AAT; Ser to Asn Urinary bladder dysplasia Chemical/Drug (1)
nucleotide 778 (codon 260), CGG->TGG; Arg to Trp Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 787 (codon 263), GGA->AGA; Gly to Arg Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 788 (codon 263), GGA->GTA; Gly to Val Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 790 (codon 264), CGG->TGG; Arg to Trp Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 791 (codon 264), CGG->CCG; Arg to Pro Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 792 (codon 264), CGG->CGA; Arg to Arg (silent) Lung adenoma Chemical/Drug (1)
nucleotide 808 (codon 270), CGT->AGT; Arg to Ser Mammary gland tumor None (spontaneous) (1)
nucleotide 809 (codon 270), CGT->CAT; Arg to His Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 809 (codon 270), CGT->CCT; Arg to Pro Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 809 (codon 270), CGT->CTT; Arg to Leu Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 824 (codon 275), TCC->TTC; Ser to Phe Skin papilloma Radiation (1)
nucleotide 827 (codon 276), GGG->GTG; Gly to Val Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 831 (codon 277), AGA->AGT; Arg to Ser Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 832 (codon 278), GAC->AAC; Asp to Asn Intestine - Large Intestine adenoma Chemical/Drug (1)
nucleotide 832 (codon 278), GAC->TAC; Asp to Tyr Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 836 (codon 279), CGC->CCC; Arg to Pro Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 841 (codon 281), ACA->GCA; Thr to Ala (Unspecified organ) tumor - malignant None (spontaneous) (2)
nucleotide 897 (codon 299), GGG->GGT; Gly to Gly (silent) Intestine - Large Intestine carcinoma Chemical/Drug (1)
nucleotide 899 (codon 300), AGC->AAC; Ser to Asn Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 901 (codon 301), GCA->ACA; Ala to Thr Intestine - Large Intestine atypia Chemical/Drug (1)
nucleotide 950 (codon 317), GAC->GGC; Asp to Gly Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 980 (codon 327), CTC->CCC; Leu to Pro Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (2)