Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search for Help
 
in these sections
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets

Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology

Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice

Send Questions and
Comments to User Support.

Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Hras
Gene Name Harvey rat sarcoma virus oncogene
Mouse Chromosome 7
Genetic Change Type Point mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
codon 12; unspecified Forestomach squamous cell carcinoma - well differentiated Chemical/Drug (2)
Oral cavity squamous cell carcinoma Chemical/Drug (1)
nucleotide 131 (codon 44), GTG->GCG; Val to Ala Urinary bladder carcinoma Chemical/Drug (2)
nucleotide 181 (codon 61), CAA->AAA; Gln to Lys Eye - Harderian gland adenoma None (spontaneous) (1)
Eye - Harderian gland adenoma Chemical/Drug (2)
Eye - Harderian gland tumor None (spontaneous) (1)
Eye - Harderian gland tumor Chemical/Drug (1)
Liver adenoma Chemical/Drug (3)
Liver adenoma Diet (1)
Liver tumor Chemical/Drug (2)
Liver tumor Radiation (2)
Liver tumor - basophilic None (spontaneous) (1)
Liver tumor - basophilic Chemical/Drug (1)
nucleotide 182 (codon 61), CAA->CGA; Gln to Arg Eye - Harderian gland adenoma None (spontaneous) (1)
Eye - Harderian gland adenoma Chemical/Drug (1)
Eye - Harderian gland tumor None (spontaneous) (1)
Eye - Harderian gland tumor Chemical/Drug (1)
Liver adenoma Chemical/Drug (1)
Liver tumor Chemical/Drug (2)
Liver tumor Radiation (1)
Liver tumor - basophilic Chemical/Drug (1)
nucleotide 182 (codon 61), CAA->CTA; Gln to Leu Eye - Harderian gland adenoma None (spontaneous) (1)
Eye - Harderian gland adenoma Chemical/Drug (2)
Eye - Harderian gland tumor None (spontaneous) (1)
Eye - Harderian gland tumor Chemical/Drug (1)
Liver adenoma Chemical/Drug (3)
Liver adenoma Diet (1)
Liver tumor Chemical/Drug (7)
Liver tumor Radiation (2)
Mammary gland adenocarcinoma - type B Chemical/Drug (1)
Mammary gland tumor None (spontaneous) (1)
Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (1)
Prostate gland - Ventral lobe prostatic intraepithelial neoplasia (PIN) None (spontaneous) (2)
Skin carcinoma Chemical/Drug (2)
Skin - Melanocyte melanoma Chemical/Drug (1)
Skin papilloma Chemical/Drug (6)
Skin squamous cell carcinoma Chemical/Drug (2)
Skin squamous cell hyperplasia Chemical/Drug (2)
Skin squamous cell papilloma Chemical/Drug (2)
nucleotide 250 (codon 84), ATC->GTC; Ile to Val Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (1)
nucleotide 267 (codon 89), TCC->TCT; Ser to Ser (silent) Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (1)
nucleotide 35 (codon 12), GGA->GTA; Gly to Val Mammary gland adenocarcinoma None (spontaneous) (1)
Urinary bladder carcinoma Chemical/Drug (1)
nucleotide 38 (codon 13), GGC->GTC; Gly to Val Forestomach papilloma Chemical/Drug (1)
Forestomach squamous cell carcinoma Chemical/Drug (1)
unspecified Oral cavity squamous cell carcinoma Chemical/Drug (1)