Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search for Help
 
in these sections
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets

Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology

Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice

Send Questions and
Comments to User Support.

Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Kras
Gene Name Kirsten rat sarcoma viral oncogene homolog
Mouse Chromosome 6
Genetic Change Type Point mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
codon 12; G:C->A:T transition Leukocyte lymphoma Chemical/Drug (1)
codon 12; unspecified Lung adenocarcinoma None (spontaneous) (1)
Lung adenocarcinoma Radiation (2)
Lung tumor Chemical/Drug (2)
Mammary gland adenocarcinoma Genetic Modification (1)
codon 13; unspecified Lung tumor Chemical/Drug (2)
codon 61; unspecified Lung tumor Chemical/Drug (3)
Mammary gland adenocarcinoma Genetic Modification (1)
nucleotide 182 (codon 61), CAA->CGA; Gln to Arg Lung adenocarcinoma None (spontaneous) (1)
Lung adenocarcinoma Chemical/Drug (4)
Lung adenoma None (spontaneous) (1)
Lung adenoma Chemical/Drug (9)
Lung adenoma Diet (1)
Lung - Alveolus hyperplasia Chemical/Drug (1)
Lung carcinoma None (spontaneous) (3)
Lung carcinoma Chemical/Drug (3)
Lung carcinoma Diet (1)
Lung hyperplasia Chemical/Drug (2)
Lung tumor None (spontaneous) (6)
Lung tumor Chemical/Drug (4)
Mammary gland tumor None (spontaneous) (1)
nucleotide 182 (codon 61), CAA->CGA; Gln to Arg
A/J point mutation
Lung adenoma None (spontaneous) (1)
Lung tumor Chemical/Drug (7)
nucleotide 182 (codon 61), CAA->CGA; Gln to Arg
C57BL/6J point mutation
Lung tumor Chemical/Drug (12)
nucleotide 182 (codon 61), CAA->CTA; Gln to Leu Eye - Harderian gland adenoma None (spontaneous) (1)
Eye - Harderian gland adenoma Chemical/Drug (2)
Lung adenocarcinoma None (spontaneous) (1)
Lung adenocarcinoma Chemical/Drug (2)
Lung adenoma None (spontaneous) (2)
Lung adenoma Chemical/Drug (8)
Lung adenoma Diet (2)
Lung adenoma - papillary None (spontaneous) (1)
Lung carcinoma None (spontaneous) (1)
Lung carcinoma Chemical/Drug (2)
Lung carcinoma Diet (2)
Lung tumor None (spontaneous) (2)
Lung tumor Chemical/Drug (4)
Mammary gland adenocarcinoma - type B Chemical/Drug (1)
nucleotide 182 (codon 61), CAA->CTA; Gln to Leu
A/J point mutation
Lung adenocarcinoma Chemical/Drug (1)
Lung adenoma None (spontaneous) (1)
Lung tumor Chemical/Drug (7)
nucleotide 182 (codon 61), CAA->CTA; Gln to Leu
C57BL/6J point mutation
Lung tumor Chemical/Drug (4)
nucleotide 183 (codon 61), CAA->CAC; Gln to His Lung adenocarcinoma Chemical/Drug (1)
Lung adenoma None (spontaneous) (1)
Lung adenoma Chemical/Drug (2)
Lung carcinoma None (spontaneous) (1)
Lung tumor None (spontaneous) (1)
Lung tumor Chemical/Drug (1)
nucleotide 183 (codon 61), CAA->CAT; Gln to His Leukocyte lymphoma Chemical/Drug (1)
Lung adenocarcinoma None (spontaneous) (1)
Lung adenocarcinoma Chemical/Drug (1)
Lung adenoma Chemical/Drug (1)
Lung tumor None (spontaneous) (5)
Lung tumor Chemical/Drug (2)
nucleotide 219 (codon 73), AGA->AGG; Arg to Arg (silent) Lung adenoma Chemical/Drug (1)
Lung hyperplasia Chemical/Drug (1)
nucleotide 225 (codon 75), GGG->GGA; Gly to Gly (silent) Lung hyperplasia Chemical/Drug (1)
nucleotide 34 (codon 12), GGT->AGT; Gly to Ser Stomach - Glandular adenocarcinoma Chemical/Drug (1)
nucleotide 34 (codon 12), GGT->CGT; Gly to Arg Lung adenoma None (spontaneous) (2)
Lung adenoma Chemical/Drug (1)
Lung carcinoma None (spontaneous) (2)
Lung tumor None (spontaneous) (4)
Lung tumor Chemical/Drug (1)
nucleotide 34 (codon 12), GGT->CGT; Gly to Arg
A/J point mutation
Lung adenoma None (spontaneous) (1)
nucleotide 34 (codon 12), GGT->TGT; Gly to Cys Eye - Harderian gland adenoma Chemical/Drug (1)
Leukocyte lymphoma Chemical/Drug (1)
Lung adenocarcinoma Chemical/Drug (1)
Lung adenoma Chemical/Drug (3)
Lung hyperplasia Chemical/Drug (1)
Lung tumor None (spontaneous) (2)
Lung tumor Chemical/Drug (1)
Mammary gland adenocarcinoma - type B Chemical/Drug (1)
nucleotide 34 (codon 12), GGT->TGT; Gly to Cys
A/J point mutation
Lung adenoma None (spontaneous) (1)
Lung adenoma Chemical/Drug (1)
nucleotide 35 (codon 12), GGT->GAT; Gly to Asp Eye - Harderian gland adenoma Chemical/Drug (1)
Intestine - Large Intestine - Colon adenocarcinoma Chemical/Drug (1)
Lung adenocarcinoma None (spontaneous) (1)
Lung adenocarcinoma Chemical/Drug (2)
Lung adenoma None (spontaneous) (2)
Lung adenoma Chemical/Drug (10)
Lung - Alveolus adenoma Chemical/Drug (3)
Lung - Alveolus hyperplasia Chemical/Drug (1)
Lung carcinoma None (spontaneous) (2)
Lung carcinoma Chemical/Drug (1)
Lung hyperplasia Chemical/Drug (1)
Lung tumor None (spontaneous) (7)
Lung tumor Chemical/Drug (6)
Mammary gland adenocarcinoma Genetic Modification (1)
Mammary gland tumor None (spontaneous) (1)
nucleotide 35 (codon 12), GGT->GAT; Gly to Asp
A/J point mutation
Lung adenoma None (spontaneous) (1)
Lung adenoma Chemical/Drug (2)
Lung tumor Chemical/Drug (2)
nucleotide 35 (codon 12), GGT->GCT; Gly to Ala Lung - Alveolus adenoma Chemical/Drug (1)
Lung tumor None (spontaneous) (1)
Lung tumor Chemical/Drug (2)
nucleotide 35 (codon 12), GGT->GTT; Gly to Val Lung adenocarcinoma Chemical/Drug (4)
Lung adenocarcinoma Genetic Modification (1)
Lung adenoma None (spontaneous) (2)
Lung adenoma Chemical/Drug (4)
Lung - Alveolus adenoma Chemical/Drug (1)
Lung - Alveolus hyperplasia Chemical/Drug (1)
Lung carcinoma None (spontaneous) (3)
Lung carcinoma Chemical/Drug (1)
Lung tumor None (spontaneous) (6)
Lung tumor Chemical/Drug (7)
Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (1)
nucleotide 35 (codon 12), GGT->GTT; Gly to Val
A/J point mutation
Lung adenoma None (spontaneous) (1)
Lung adenoma Chemical/Drug (1)
nucleotide 37 (codon 13), GGC->CGC; Gly to Arg Eye - Harderian gland adenoma Chemical/Drug (2)
Liver hepatocellular adenoma Chemical/Drug (1)
Liver hepatocellular carcinoma Chemical/Drug (1)
Liver tumor Chemical/Drug (5)
Lung adenocarcinoma Chemical/Drug (1)
Lung adenoma Chemical/Drug (1)
Lung carcinoma None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)