Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search for Help
 
in these sections
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets

Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology

Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice

Send Questions and
Comments to User Support.

Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Cdkn2a
Gene Name cyclin dependent kinase inhibitor 2A
Mouse Chromosome 4
Genetic Change Type Point mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
codon 12; Ala to Val
p16Ink4a point mutation
Skin - Melanocyte melanoma None (spontaneous) (1)
nucleotide 218 (codon 73), CCG->CTG; Pro to Leu Liver hepatocellular adenoma Chemical/Drug (1)
Liver hepatocellular carcinoma Chemical/Drug (1)
nucleotide 35 (codon 12), GCG->GTG; Ala to Val Liver hepatocellular carcinoma Chemical/Drug (1)
nucleotide 80 (codon 27), GGG->GAG; Gly to Glu Liver hepatocellular carcinoma Chemical/Drug (1)
nucleotide 82 (codon 28), GTT->ATT; Val to Ile Liver hepatocellular carcinoma Chemical/Drug (1)
nucleotide 87 (codon 29), TCG->TCA; Ser to Ser (silent) Liver hepatocellular carcinoma Chemical/Drug (1)
nucleotide 93 (codon 31), AAC->AAT; Asn to Asn (silent) Liver hepatocellular carcinoma Chemical/Drug (1)