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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Apc
Gene Name APC, WNT signaling pathway regulator
Mouse Chromosome 18
Genetic Change Type Point mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
nucleotide 2114 (codon 705), CTC->CCC; Leu to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2177 (codon 726), AAT->AGT; Asn to Ser Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2249 (codon 750), CTT->CCT; Leu to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2308 (codon 770), ACC->GCC; Thr to Ala Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2383 (codon 795), GGT->AGT; Gly to Ser Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2411 (codon 804), CAT->CGT; His to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2413 (codon 805), GAT->AAT; Asp to Asn Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2459 (codon 820), CTT->CCT; Leu to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2618 (codon 873), AAA->AGA; Lys to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2647 (codon 883), GCC->ACC; Ala to Thr Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2707 (codon 903), AGT->CGT; Ser to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2770 (codon 924), TCT->CCT; Ser to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3007 (codon 1003), GCC->CCC; Ala to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3020 (codon 1007), CAC->CGC; His to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3175 (codon 1059), AAG->GAG; Lys to Glu Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3179 (codon 1060), CAA->CTA; Gln to Leu Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3185 (codon 1062), GAG->GGG; Glu to Gly Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3247 (codon 1083), AAA->GAA; Lys to Glu Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3253 (codon 1085), CTC->GTC; Leu to Val Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3254 (codon 1085), CTC->CCC; Leu to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3263 (codon 1088), CAA->CGA; Glu to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3278 (codon 1093), CAA->CGA; Gln to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3370 (codon 1124), AAC->GAC; Asn to Asp Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3382 (codon 1128), TGT->CGT; Cys to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3413 (codon 1138), CCT->CTT; Pro to Leu Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3449 (codon 1150), CAA->CGA; Gln to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3559 (codon 1187), TCT->CCT; Ser to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3617 (codon 1206), AAA->AGA; Lys to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3677 (codon 1226), AGG->AAG; Arg to Lys Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3686 (codon 1229), CAG->CGG; Gln to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3739 (codon 1247), TGC->CGC; Cys to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3742 (codon 1248), AAA->GAA; Lys to Glu Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3805 (codon 1269), TTT->CTT; Phe to Leu Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3808 (codon 1270), TCA->CCA; Ser to Pro Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3811 (codon 1271), AGG->GGG; Arg to Gly Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3904 (codon 1302), ACA->GCA; Thr to Ala Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 3926 (codon 1309), GAT->GGT; Asp to Gly Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4127 (codon 1376), GTC->GCC; Val to Ala Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4154 (codon 1385), AGG->AAG; Arg to Lys Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4156 (codon 1386), TGT->CGT; Cys to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4192 (codon 1398), CGC->AGC; Arg to Ser Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4244 (codon 1415), GGC->GAC; Gly to Asp Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4421 (codon 1474), GCC->GTC; Ala to Val Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4477 (codon 1493), GAA->AAA; Glu to Lys Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4501 (codon 1501), TGT->CGT; Cys to Arg Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4508 (codon 1503), TCC->TTC; Ser to Phe Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4592 (codon 1531), GAC->GGC; Asp to Gly Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4600 (codon 1534), AAT->GAT; Asn to Asp Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4606 (codon 1536), ACT->GCT; Thr to Ala Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)