Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Trp53
Gene Name transformation related protein 53
Mouse Chromosome 11
Genetic Change Type Normal

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
exons 2-11
wild type Trp53
Leukocyte lymphoma None (spontaneous) (2)
Muscle - Smooth leiomyosarcoma None (spontaneous) (1)
Ovary - Granulosa cell tumor None (spontaneous) (1)
Skin - Epidermis - Basal cell carcinoma None (spontaneous) (1)
(Unspecified organ) carcinoma - adenosquamous None (spontaneous) (1)
exons 5-10
wild type Trp53
Bone osteosarcoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (1)
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma None (spontaneous) (1)
Ovary - Granulosa cell tumor None (spontaneous) (1)
Skin - Epidermis - Basal cell carcinoma None (spontaneous) (2)
(Unspecified organ) carcinoma - adenosquamous None (spontaneous) (1)
exons 5-9
wild type Trp53
Mammary gland carcinoma None (spontaneous) (1)
Trp53+
wild type
Adipose tissue liposarcoma None (spontaneous) (1)
Blood vessel hemangioma Chemical/Drug (4)
Blood vessel hemangiosarcoma None (spontaneous) (3)
Blood vessel hemangiosarcoma Chemical/Drug (4)
Bone osteosarcoma None (spontaneous) (9)
Bone osteosarcoma Radiation (1)
CNS - Brain - Astrocyte astrocytoma None (spontaneous) (3)
CNS - Brain - Cerebellum medulloblastoma None (spontaneous) (2)
CNS - Brain - Choroid plexus tumor None (spontaneous) (1)
CNS - Brain glioblastoma None (spontaneous) (1)
CNS - Brain - Undifferentiated cell medulloblastoma None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma Chemical/Drug (2)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (3)
Ear - Outer ear - Ear canal squamous cell carcinoma None (spontaneous) (2)
Ear squamous cell carcinoma None (spontaneous) (1)
Forestomach papilloma Chemical/Drug (2)
Forestomach squamous cell carcinoma Chemical/Drug (1)
Forestomach squamous cell carcinoma - well differentiated Chemical/Drug (2)
Intestine adenoma - macroadenoma None (spontaneous) (4)
Intestine - Large Intestine adenoma Chemical/Drug (3)
Intestine - Large Intestine atypia Chemical/Drug (1)
Intestine - Large Intestine carcinoma Chemical/Drug (1)
Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
Intestine - Large Intestine - Colon carcinoma None (spontaneous) (1)
Intestine - Small Intestine adenoma None (spontaneous) (1)
Intestine - Small Intestine - Duodenum polyp None (spontaneous) (1)
Intestine tumor None (spontaneous) (2)
Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (2)
Leukocyte - Lymphocyte - Immature T-lymphocyte lymphoma Genetic Modification (1)
Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma - lymphoblastic Virus (1)
Leukocyte - Lymphocyte - Thymocyte lymphoma None (spontaneous) (2)
Leukocyte lymphoma None (spontaneous) (10)
Leukocyte lymphoma Genetic Modification (1)
Leukocyte - Monocyte leukemia - myelocytic Genetic Modification (1)
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma None (spontaneous) (3)
Leukocyte - Myelocyte (Granulocyte) hyperplasia Genetic Modification (2)
Leukocyte - Myelocyte (Granulocyte) leukemia None (spontaneous) (1)
Liver - Bile duct cholangiocarcinoma None (spontaneous) (1)
Liver - Bile duct cholangiocarcinoma Genetic Modification (1)
Liver hepatocellular carcinoma None (spontaneous) (3)
Liver hepatocellular carcinoma Chemical/Drug (1)
Liver hepatoma Genetic Modification (1)
Liver lesion Chemical/Drug (1)
Liver - Oval cell hyperplasia Genetic Modification (1)
Liver tumor Chemical/Drug (5)
Lung adenocarcinoma None (spontaneous) (4)
Lung adenocarcinoma Genetic Modification (1)
Lung adenoma Genetic Modification (1)
Lung adenoma - cuboidal None (spontaneous) (1)
Lung hyperplasia Chemical/Drug (1)
Lung lesion Genetic Modification (2)
Lung tumor None (spontaneous) (3)
Lung tumor Chemical/Drug (2)
Lung tumor Genetic Modification (1)
Lymphoid tissue lymphoma None (spontaneous) (3)
Mammary gland adenocarcinoma None (spontaneous) (7)
Mammary gland adenocarcinoma Chemical/Drug (1)
Mammary gland carcinoma None (spontaneous) (11)
Mammary gland carcinoma Chemical/Drug (1)
Mammary gland carcinoma - adenosquamous None (spontaneous) (1)
Mammary gland carcinoma - adenosquamous Chemical/Drug (1)
Mammary gland carcinoma - papillary None (spontaneous) (1)
Mammary gland carcinoma - papillary Chemical/Drug (1)
Mammary gland carcinoma - solid None (spontaneous) (1)
Mammary gland carcinoma - solid Chemical/Drug (1)
Mammary gland carcinosarcoma None (spontaneous) (1)
Mammary gland carcinosarcoma Chemical/Drug (1)
Mammary gland hyperplasia None (spontaneous) (1)
Mammary gland hyperplasia Chemical/Drug (2)
Mammary gland mammary intraepithelial neoplasia (MIN) None (spontaneous) (1)
Mammary gland mammary intraepithelial neoplasia (MIN) Chemical/Drug (1)
Mammary gland tumor None (spontaneous) (12)
Mammary gland tumor Chemical/Drug (1)
Mammary gland tumor - pilar None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (8)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (3)
Mesodermal cell/mesoblast sarcoma - unclassified None (spontaneous) (2)
Mesothelium mesothelioma - malignant Genetic Modification (2)
Mesothelium mesothelioma - malignant - biphasic Genetic Modification (1)
Mesothelium mesothelioma - malignant - epithelial Genetic Modification (1)
Mesothelium mesothelioma - malignant - sarcomatoid Genetic Modification (1)
Muscle - Smooth leiomyoma Genetic Modification (1)
Muscle - Smooth leiomyosarcoma None (spontaneous) (2)
Muscle - Striated - Skeletal rhabdomyosarcoma None (spontaneous) (4)
Muscle - Striated - Skeletal rhabdomyosarcoma Genetic Modification (1)
Oral cavity papilloma Genetic Modification (2)
Pancreas - Acinar cell carcinoma None (spontaneous) (1)
Pancreas adenocarcinoma None (spontaneous) (1)
Pancreas adenocarcinoma - ductal None (spontaneous) (7)
Pancreas carcinoma None (spontaneous) (2)
Pancreas - Duct pancreatic intraepithelial neoplasia (PanIN) None (spontaneous) (3)
Pancreas tumor None (spontaneous) (1)
PNS - Schwann cell neurofibrosarcoma None (spontaneous) (1)
PNS - Schwann cell schwannoma Genetic Modification (1)
Prepuce adenoma None (spontaneous) (1)
Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (3)
Prostate gland - Ventral lobe prostatic intraepithelial neoplasia (PIN) None (spontaneous) (5)
Renal pelvis carcinoma Chemical/Drug (1)
Renal pelvis squamous cell carcinoma Chemical/Drug (1)
Renal pelvis transitional cell carcinoma Chemical/Drug (1)
Salivary gland carcinoma None (spontaneous) (1)
Skin - Melanocyte melanoma None (spontaneous) (4)
Skin - Melanocyte melanoma Chemical/Drug (1)
Skin papilloma Chemical/Drug (1)
Skin papilloma Radiation (1)
Skin squamous cell carcinoma Chemical/Drug (2)
Skin squamous cell carcinoma Radiation (1)
Skin squamous cell carcinoma None (spontaneous) (1)
Skin tumor None (spontaneous) (3)
Skin tumor Chemical/Drug (1)
Stomach - Glandular adenocarcinoma Chemical/Drug (1)
Stomach - Glandular hyperplasia - adenomatous Chemical/Drug (1)
Stomach - Glandular papilloma Chemical/Drug (1)
Stomach - Glandular polyp None (spontaneous) (1)
Stomach - Glandular squamous cell carcinoma Chemical/Drug (1)
Thoracic cavity tumor Genetic Modification (1)
Urinary bladder carcinoma Chemical/Drug (4)
Urinary bladder carcinoma in situ None (spontaneous) (2)
Urinary bladder carcinoma in situ Chemical/Drug (2)
Urinary bladder dysplasia Chemical/Drug (2)
Urinary bladder squamous cell carcinoma Chemical/Drug (2)
Urinary bladder transitional cell carcinoma None (spontaneous) (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
Urinary bladder tumor - papillary None (spontaneous) (1)
(Unspecified organ) adenocarcinoma None (spontaneous) (1)
(Unspecified organ) angiosarcoma None (spontaneous) (1)
(Unspecified organ) carcinoma None (spontaneous) (2)
(Unspecified organ) squamous cell carcinoma None (spontaneous) (3)
(Unspecified organ) squamous cell papilloma None (spontaneous) (1)
(Unspecified organ) tumor None (spontaneous) (33)
(Unspecified organ) tumor Genetic Modification (1)