Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Kras
Gene Name Kirsten rat sarcoma viral oncogene homolog
Mouse Chromosome 6
Genetic Change Type Normal

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Krasa
a variant
Lung adenoma Chemical/Drug (3)
Lung tumor Chemical/Drug (6)
Krasb
b variant
Lung adenocarcinoma Chemical/Drug (1)
Lung adenoma None (spontaneous) (1)
Lung adenoma Chemical/Drug (6)
Lung tumor Chemical/Drug (16)
Kras+
wild type
Intestine adenocarcinoma - mucinous None (spontaneous) (1)
Intestine adenoma None (spontaneous) (1)
Intestine - Large Intestine - Colon adenocarcinoma Chemical/Drug (3)
Intestine - Large Intestine - Colon adenoma None (spontaneous) (1)
Intestine - Large Intestine - Colon carcinoma None (spontaneous) (1)
Intestine - Small Intestine - Duodenum polyp None (spontaneous) (1)
Intestine tumor None (spontaneous) (2)
Intestine tumor Chemical/Drug (1)
Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte lymphoma None (spontaneous) (6)
Leukocyte lymphoma Chemical/Drug (1)
Liver adenoma Chemical/Drug (4)
Liver carcinoma Chemical/Drug (3)
Liver tumor Chemical/Drug (6)
Liver tumor Not Specified (1)
Lung adenocarcinoma Chemical/Drug (8)
Lung adenocarcinoma Genetic Modification (39)
Lung adenocarcinoma None (spontaneous) (4)
Lung adenocarcinoma - papillary None (spontaneous) (1)
Lung adenoma None (spontaneous) (2)
Lung adenoma Chemical/Drug (2)
Lung adenoma Genetic Modification (4)
Lung adenoma - papillary Genetic Modification (3)
Lung - Alveolus adenocarcinoma None (spontaneous) (4)
Lung - Alveolus - Type II cell tumor Genetic Modification (1)
Lung - Bronchiole dysplasia Genetic Modification (3)
Lung - Bronchiole - Epithelium adenocarcinoma Chemical/Drug (6)
Lung - Bronchiole - Epithelium adenocarcinoma Genetic Modification (14)
Lung - Bronchiole hyperplasia Genetic Modification (3)
Lung carcinoma None (spontaneous) (1)
Lung carcinoma Chemical/Drug (1)
Lung carcinoma Genetic Modification (1)
Lung carcinoma - adenosquamous Genetic Modification (7)
Lung carcinoma - large cell (LCC) Genetic Modification (2)
Lung - Club cell tumor Genetic Modification (1)
Lung hyperplasia Genetic Modification (4)
Lung squamous cell carcinoma Genetic Modification (8)
Lung tumor None (spontaneous) (2)
Lung tumor Chemical/Drug (6)
Lung tumor Genetic Modification (15)
Mammary gland adenocarcinoma None (spontaneous) (1)
Mammary gland adenocarcinoma Genetic Modification (1)
Mammary gland hyperplasia None (spontaneous) (1)
Mammary gland tumor None (spontaneous) (6)
Mammary gland tumor Chemical/Drug (2)
Mammary gland tumor Hormone (2)
Mammary gland tumor - pilar None (spontaneous) (1)
Oral cavity squamous cell papilloma Genetic Modification (1)
Pancreas adenocarcinoma - ductal None (spontaneous) (21)
Pancreas adenocarcinoma - ductal Chemical/Drug (6)
Pancreas - Duct cyst None (spontaneous) (4)
Pancreas - Duct pancreatic intraepithelial neoplasia (PanIN) None (spontaneous) (8)
Pancreas pancreatic intraepithelial neoplasia (PanIN) None (spontaneous) (4)
Pancreas tumor None (spontaneous) (1)
Prostate gland - Ventral lobe adenocarcinoma None (spontaneous) (3)
Prostate gland - Ventral lobe prostatic intraepithelial neoplasia (PIN) None (spontaneous) (5)
Skin - Dorsal region carcinoma - spindle cell Chemical/Drug (1)
Skin - Dorsal region dysplasia - squamous Chemical/Drug (1)
Skin - Dorsal region papilloma Chemical/Drug (3)
Skin - Dorsal region squamous cell carcinoma Chemical/Drug (5)
Skin - Dorsal region squamous cell carcinoma - moderately differentiated Chemical/Drug (1)
Skin - Dorsal region squamous cell carcinoma - well differentiated Chemical/Drug (1)
Skin - Dorsal region tumor Chemical/Drug (4)
Skin - Dorsal region tumor - epidermoid Chemical/Drug (1)
Skin - Dorsal region tumor - malignant Chemical/Drug (1)
Skin gland - Sebaceous gland adenoma - sebaceous Chemical/Drug (1)
Skin - Hair follicle - Basal cell carcinoma Chemical/Drug (1)
Skin - Hair follicle - Basal cell squamous cell carcinoma Chemical/Drug (2)
Skin - Hair follicle - Basal cell trichoepithelioma Chemical/Drug (1)
Skin - Melanocyte melanoma Chemical/Drug (1)
Skin - Melanocyte melanoma - amelanotic Genetic Modification (1)
Skin papilloma None (spontaneous) (6)
Skin squamous cell carcinoma Chemical/Drug (3)
Skin tumor Chemical/Drug (7)
Stomach - Glandular hyperplasia - adenomatous Chemical/Drug (1)
Stomach - Glandular polyp None (spontaneous) (1)
Stomach - Glandular squamous cell carcinoma Chemical/Drug (1)
Thyroid gland - Follicular cell carcinoma - anaplastic None (spontaneous) (1)
(Unspecified organ) squamous cell carcinoma None (spontaneous) (1)
(Unspecified organ) squamous cell papilloma None (spontaneous) (1)