Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Apc
Gene Name APC, WNT signaling pathway regulator
Mouse Chromosome 18
Genetic Change Type Normal

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies

wild type JH102 sequence in Apc coding region
Intestine - Large Intestine - Colon adenocarcinoma Chemical/Drug (1)
Apc+
wild type
Gastrointestinal tract tumor None (spontaneous) (5)
Intestine adenoma None (spontaneous) (5)
Intestine adenoma Chemical/Drug (1)
Intestine adenoma - macroadenoma None (spontaneous) (1)
Intestine - Large Intestine adenoma None (spontaneous) (2)
Intestine - Large Intestine - Colon adenoma None (spontaneous) (5)
Intestine - Large Intestine - Colon adenoma Chemical/Drug (4)
Intestine - Large Intestine - Colon - Proximal foci - aberrant crypt (ACF) Not Specified (1)
Intestine - Large Intestine - Colon tumor None (spontaneous) (1)
Intestine - Large Intestine - Colon tumor Chemical/Drug (3)
Intestine - Small Intestine adenoma None (spontaneous) (6)
Intestine - Small Intestine adenoma Chemical/Drug (3)
Intestine - Small Intestine - Ileum adenoma None (spontaneous) (1)
Intestine - Small Intestine - Jejunum adenoma None (spontaneous) (1)
Intestine - Small Intestine tumor None (spontaneous) (2)
Intestine - Small Intestine tumor Chemical/Drug (7)
Intestine tumor None (spontaneous) (4)
Intestine tumor Chemical/Drug (1)
Intestine tumor Radiation (2)
Leukocyte lymphoma None (spontaneous) (1)
Liver hepatocellular carcinoma Genetic Modification (1)
Liver - Hepatocyte hyperplasia Genetic Modification (1)
Liver tumor Genetic Modification (1)
Lung tumor None (spontaneous) (2)
Mammary gland adenocarcinoma None (spontaneous) (1)
Mammary gland carcinoma - adenosquamous None (spontaneous) (2)
Mammary gland carcinoma - adenosquamous Radiation (3)
Mammary gland tumor None (spontaneous) (5)
Mammary gland tumor - acinar None (spontaneous) (1)
Mammary gland tumor - basosquamous None (spontaneous) (1)
Mammary gland tumor - pilar None (spontaneous) (1)
Mammary gland tumor - undifferentiated None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (1)