Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Trp53
Gene Name transformation related protein 53
Mouse Chromosome 11
Genetic Change Type Nonsense mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
nucleotide 301 (codon 101), CAG->TAG; Gln to Stop Liver hepatocellular carcinoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (1)
(Unspecified organ) tumor - solid - malignant None (spontaneous) (1)
nucleotide 429 (codon 143), TGG->TGA; Trp to Stop Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
(Unspecified organ) tumor - malignant None (spontaneous) (2)
nucleotide 490 (codon 164), CAG->TAG; Gln to Stop Urinary bladder dysplasia Chemical/Drug (1)
nucleotide 586 (codon 196), GGA->TGA; Gly to Stop Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
nucleotide 597 (codon 199), TAT->TAA; Tyr to Stop Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (3)
nucleotide 597 (codon 199), TAT->TAG; Tyr to Stop Urinary bladder squamous cell carcinoma Chemical/Drug (1)
nucleotide 606 (codon 202), TAT->TAG; Tyr to Stop Urinary bladder carcinoma Chemical/Drug (1)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma Chemical/Drug (1)
Q112STOP (Unspecified organ) tumor None (spontaneous) (1)
Q141STOP Leukocyte lymphoma None (spontaneous) (1)
(Unspecified organ) tumor None (spontaneous) (1)