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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Apc
Gene Name APC, WNT signaling pathway regulator
Mouse Chromosome 18
Genetic Change Type Nonsense mutation

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Mammary gland tumor - acinar None (spontaneous) (1)
codon 1076; Stop Intestine tumor Chemical/Drug (1)
codon 1094; Stop Intestine tumor Chemical/Drug (1)
codon 1150; Stop Intestine tumor Chemical/Drug (1)
codon 1189; Stop Intestine tumor Chemical/Drug (1)
codon 1190; Stop Intestine tumor Chemical/Drug (1)
codon 1197; Stop Intestine tumor Chemical/Drug (1)
codon 971; Stop Intestine tumor Chemical/Drug (1)
codon 998; Stop Intestine tumor Chemical/Drug (1)
nucleotide 2305 (codon 769), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2338 (codon 780), AAG->TAG; Lys to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2407 (codon 803), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (4)
Intestine tumor None (spontaneous) (1)
nucleotide 2443 (codon 815), GGA->TGA; Gln to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 2459 (codon 820), TTG->TAG; Leu to Stop Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 2509 (codon 837), GGA->TGA; Gly to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2560 (codon 854), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (5)
Intestine - Small Intestine tumor None (spontaneous) (2)
Intestine tumor None (spontaneous) (1)
nucleotide 2596 (codon 866), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 2605 (codon 869), GGA->TGA; Gly to Stop Gastrointestinal tract tumor None (spontaneous) (1)
Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 2620 (codon 874), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (6)
Intestine - Small Intestine tumor None (spontaneous) (1)
nucleotide 2650 (codon 884), CAG->TAG; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 2695 (codon 899), CAG->TAG; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2725 (codon 909), GAG->TAG; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2761 (codon 921), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (7)
Intestine tumor None (spontaneous) (1)
nucleotide 2799 (codon 933), TAC->TAA; Tyr to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2815 (codon 939), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (5)
Intestine - Large Intestine - Colon tumor Chemical/Drug (1)
nucleotide 2822 (codon 941), TCA->TAA; Ser to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2835 (codon 945), TGC->TGA; Cys to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 2835 (codon 945), TGC->TGT; Cys to Stop Intestine - Small Intestine tumor None (spontaneous) (1)
nucleotide 2866 (codon 956), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (8)
Intestine - Small Intestine adenoma Chemical/Drug (1)
Intestine - Small Intestine tumor None (spontaneous) (2)
Intestine tumor None (spontaneous) (1)
nucleotide 2908 (codon 970), GGA->TGA; Gly to Stop Gastrointestinal tract tumor None (spontaneous) (1)
Intestine tumor None (spontaneous) (1)
nucleotide 2944 (codon 982), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2952 (codon 984), TAT->TAA; Tyr to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 2965 (codon 989), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
Intestine - Small Intestine tumor Chemical/Drug (2)
nucleotide 2979 (codon 993), TGC->TGA; Cys to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3049 (codon 1017), GGA->TGA; Gly to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 3052 (codon 1018), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 3075 (codon 1025), TAC->TAA; Tyr to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3140 (codon 1047), TGG->TAG; Trp to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3141 (codon 1047), TGG->TGA; Trp to Stop Gastrointestinal tract tumor None (spontaneous) (5)
nucleotide 3163 (codon 1055), GAA->TAA; Glu to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3169 (codon 1057), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3184 (codon 1062), GAG->TAG; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
Intestine - Small Intestine tumor Chemical/Drug (1)
Intestine tumor None (spontaneous) (1)
nucleotide 3193 (codon 1065), CAA->TAA; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3262 (codon 1088), CAA->TAA; Gln to Stop Intestine - Small Intestine tumor None (spontaneous) (1)
nucleotide 3283 (codon 1095), GAA->TAA; Glu to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3310 (codon 1104), GGA->TGA; Gly to Stop Intestine - Small Intestine tumor Chemical/Drug (2)
nucleotide 3323 (codon 1108), TCA->TGA; Ser to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3325 (codon 1109), GAA->TAA; Glu to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3334 (codon 1112), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (3)
nucleotide 3388 (codon 1130), GAA->TAA; Glu to Stop Intestine - Small Intestine adenoma Chemical/Drug (1)
Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3423 (codon 1141), TAC->TAA; Tyr to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3427 (codon 1143), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (1)
Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3457 (codon 1153), GAA->TAA; Glu to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3460 (codon 1154), GAA->TAA; Glu to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 3466 (codon 1156), GAG->TAG; Glu to Stop Intestine - Small Intestine tumor Chemical/Drug (1)
nucleotide 3584 (codon 1195), TCA->TAA; Ser to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3679 (codon 1227), CAG->TAG; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (4)
nucleotide 3701 (codon 1234), TCA->TAA; Ser to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3706 (codon 1236), CAA->TAA; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3724 (codon 1242), CAA->TAA; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3772 (codon 1258), CAG->TAG; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (2)
nucleotide 3816 (codon 1272), TGC->TGA; Cys to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 3821 (codon 1274), TCA->TAA; Ser to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 4000 (codon 1334), CGA->TGA; Arg to Stop Gastrointestinal tract tumor None (spontaneous) (1)
nucleotide 4006 (codon 1336), CAG->TAG; Gln to Stop Gastrointestinal tract tumor None (spontaneous) (1)
Intestine - Large Intestine - Colon tumor Chemical/Drug (1)
nucleotide 4402 (codon 1468), CAG->TAG; Gln to Stop Intestine - Large Intestine - Colon adenocarcinoma None (spontaneous) (1)
nucleotide 4582 (codon 1528), CAG->TAG; Gln to Stop Mammary gland tumor None (spontaneous) (2)
nucleotide 4585 (codon 1529), GAA->TAA; Glu to Stop Mammary gland tumor None (spontaneous) (1)
nucleotide 4624 (codon 1542), GAG->TAG; Glu to Stop Mammary gland tumor None (spontaneous) (1)
nucleotide 4636 (codon 1546), GAA->TAA; Glu to Stop Mammary gland tumor None (spontaneous) (1)
Mammary gland tumor - pilar None (spontaneous) (1)
nucleotide 4657 (codon 1553), GAA->TAA; Glu to Stop Mammary gland tumor None (spontaneous) (1)
nucleotide 4681 (codon 1561), AAA->TAA; Lys to Stop Mammary gland tumor None (spontaneous) (1)