Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Trp53
Gene Name transformation related protein 53
Mouse Chromosome 11
Genetic Change Type Loss of heterozygosity

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Blood vessel hemangiosarcoma None (spontaneous) (2)
Bone osteosarcoma None (spontaneous) (12)
Bone osteosarcoma Radiation (1)
Bone osteosarcoma - anaplastic None (spontaneous) (1)
Bone tumor None (spontaneous) (1)
CNS - Brain - Astrocyte astrocytoma None (spontaneous) (3)
CNS - Brain - Choroid plexus tumor None (spontaneous) (3)
CNS - Brain glioblastoma None (spontaneous) (1)
CNS - Brain medulloblastoma None (spontaneous) (2)
CNS - Brain - Oligodendroglial cell oligodendroglioma None (spontaneous) (1)
Connective tissue - Fibroblast fibrosarcoma None (spontaneous) (3)
Ear - Outer ear - Ear canal squamous cell carcinoma None (spontaneous) (4)
Ear squamous cell carcinoma None (spontaneous) (1)
Leukocyte - Lymphocyte - B-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - Immature T-lymphocyte lymphoma Genetic Modification (1)
Leukocyte - Lymphocyte lymphoma None (spontaneous) (2)
Leukocyte - Lymphocyte - Pre-B-lymphocyte lymphoma - lymphoblastic Virus (1)
Leukocyte - Lymphocyte - Pro-B-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - Thymocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - T-lymphocyte lymphoma None (spontaneous) (1)
Leukocyte - Lymphocyte - T-lymphocyte lymphoma Radiation (1)
Leukocyte lymphoma None (spontaneous) (10)
Leukocyte lymphoma Chemical/Drug (4)
Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma None (spontaneous) (1)
Leukocyte - Myelocyte (Granulocyte) leukemia None (spontaneous) (1)
Leukocyte - Myelocyte (Granulocyte) leukemia - chronic myeloid (CML) None (spontaneous) (1)
Liver hepatocellular carcinoma Chemical/Drug (1)
Liver tumor Chemical/Drug (1)
Lung adenocarcinoma Genetic Modification (4)
Lung adenocarcinoma None (spontaneous) (2)
Lung adenoma - cuboidal None (spontaneous) (1)
Lung carcinoma - small cell lung (SCLC) Genetic Modification (1)
Lung lesion Genetic Modification (1)
Lymphoid tissue lymphoma None (spontaneous) (3)
Mammary gland adenocarcinoma None (spontaneous) (5)
Mammary gland carcinoma None (spontaneous) (7)
Mammary gland carcinoma - lobular None (spontaneous) (1)
Mammary gland carcinosarcoma None (spontaneous) (1)
Mammary gland tumor None (spontaneous) (14)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (2)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (5)
Mesodermal cell/mesoblast sarcoma - anaplastic None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma - spindle cell Genetic Modification (1)
Muscle sarcoma - unclassified None (spontaneous) (1)
Muscle - Smooth leiomyosarcoma None (spontaneous) (2)
Muscle - Striated - Skeletal rhabdomyosarcoma None (spontaneous) (6)
Myoepithelial cell myoepithelioma None (spontaneous) (1)
Ovary carcinoma Genetic Modification (1)
Ovary carcinoma - stage IIIA Genetic Modification (2)
Ovary carcinoma - stage IV Genetic Modification (1)
Pancreas - Acinar cell carcinoma - acinar Chemical/Drug (1)
Pancreas adenocarcinoma - ductal None (spontaneous) (3)
Pancreas adenocarcinoma - ductal Chemical/Drug (6)
Pancreas carcinoma None (spontaneous) (2)
Pancreas cystadenoma - serous None (spontaneous) (2)
Pancreas - Islet of Langerhans carcinoma None (spontaneous) (1)
Pancreas - Islet of Langerhans tumor None (spontaneous) (1)
Pancreas tumor None (spontaneous) (1)
Pineal gland pineoblastoma None (spontaneous) (1)
PNS - Ganglion - Dorsal root tumor None (spontaneous) (1)
PNS - Nerve sheath tumor - malignant None (spontaneous) (2)
PNS - Nerve tumor None (spontaneous) (2)
Salivary gland tumor None (spontaneous) (2)
Skin carcinoma None (spontaneous) (1)
Skin - Melanocyte melanoma None (spontaneous) (1)
Skin squamous cell carcinoma None (spontaneous) (1)
Skin tumor None (spontaneous) (3)
Thymus thymoma None (spontaneous) (1)
Thyroid gland - Medulla carcinoma None (spontaneous) (1)
Urinary bladder carcinoma in situ None (spontaneous) (2)
Urinary bladder squamous cell carcinoma Chemical/Drug (1)
Urinary bladder transitional cell carcinoma None (spontaneous) (1)
Urinary bladder - Transitional cell carcinoma Chemical/Drug (1)
Urinary bladder tumor Chemical/Drug (1)
Urinary bladder tumor - papillary None (spontaneous) (1)
Uterus adenocarcinoma None (spontaneous) (1)
Uterus - Endometrium tumor None (spontaneous) (1)
(Unspecified organ) adenocarcinoma None (spontaneous) (2)
(Unspecified organ) angiosarcoma None (spontaneous) (1)
(Unspecified organ) carcinoma None (spontaneous) (1)
(Unspecified organ) squamous cell carcinoma None (spontaneous) (2)
(Unspecified organ) tumor None (spontaneous) (44)
(Unspecified organ) tumor Chemical/Drug (1)