Mouse Tumor Biology Database (MTB)
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Last Database Update
MTB 3.0
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Nf1
Gene Name neurofibromin 1
Mouse Chromosome 11
Genetic Change Type Loss of heterozygosity

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Adrenal gland - Medulla pheochromocytoma None (spontaneous) (1)
Bone osteosarcoma Radiation (1)
CNS - Brain - Astrocyte astrocytoma None (spontaneous) (3)
CNS - Brain glioblastoma None (spontaneous) (1)
Leukocyte lymphoma None (spontaneous) (1)
Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic None (spontaneous) (1)
Lung adenocarcinoma None (spontaneous) (1)
Mesodermal cell/mesoblast sarcoma None (spontaneous) (1)

C57BL/6J allele
Mammary gland adenocarcinoma Chemical/Drug (1)
Mammary gland adenocarcinoma Radiation (1)
Mesodermal cell/mesoblast sarcoma Chemical/Drug (1)
Mesodermal cell/mesoblast sarcoma Radiation (1)