Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-10
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Apc
Gene Name APC, WNT signaling pathway regulator
Mouse Chromosome 18
Genetic Change Type Loss of heterozygosity

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Connective tissue - Fibroblast desmoid None (spontaneous) (4)
Gastrointestinal tract adenoma None (spontaneous) (3)
Gastrointestinal tract carcinoma None (spontaneous) (1)
Gastrointestinal tract polyp None (spontaneous) (1)
Intestine adenocarcinoma None (spontaneous) (3)
Intestine adenoma None (spontaneous) (26)
Intestine adenoma Radiation (2)
Intestine adenoma - macroadenoma None (spontaneous) (2)
Intestine adenoma - microadenoma None (spontaneous) (2)
Intestine carcinoma in situ None (spontaneous) (1)
Intestine dysplasia None (spontaneous) (3)
Intestine dysplasia Genetic Modification (1)
Intestine - Large Intestine adenoma None (spontaneous) (3)
Intestine - Large Intestine - Colon adenoma None (spontaneous) (10)
Intestine - Large Intestine - Colon adenoma Chemical/Drug (3)
Intestine - Large Intestine - Colon polyp None (spontaneous) (3)
Intestine - Large Intestine - Colon polyp Not Specified (1)
Intestine - Large Intestine - Colon tumor None (spontaneous) (1)
Intestine - Large Intestine - Colon tumor Chemical/Drug (4)
Intestine lesion Genetic Modification (1)
Intestine polyp - adenomatous None (spontaneous) (3)
Intestine - Small Intestine adenoma None (spontaneous) (11)
Intestine - Small Intestine adenoma Chemical/Drug (4)
Intestine - Small Intestine - Duodenum adenoma None (spontaneous) (2)
Intestine - Small Intestine dysplasia None (spontaneous) (2)
Intestine - Small Intestine - Ileum adenoma None (spontaneous) (3)
Intestine - Small Intestine - Jejunum adenoma None (spontaneous) (3)
Intestine - Small Intestine polyp None (spontaneous) (5)
Intestine - Small Intestine polyp Not Specified (1)
Intestine - Small Intestine tumor None (spontaneous) (2)
Intestine - Small Intestine tumor Chemical/Drug (8)
Intestine - Small Intestine tumor Not Specified (1)
Intestine tumor None (spontaneous) (8)
Intestine tumor Chemical/Drug (1)
Intestine tumor Radiation (3)
Mammary gland adenocarcinoma None (spontaneous) (1)
Mammary gland tumor None (spontaneous) (1)
Ovary - Sex cord stromal cell tumor Radiation (1)
Pancreas - Acinar cell adenocarcinoma None (spontaneous) (2)
Pancreas - Acinar cell adenoma None (spontaneous) (1)
Pancreas dysplasia None (spontaneous) (1)
Skin gland - Sebaceous gland cyst None (spontaneous) (2)
Stomach adenoma None (spontaneous) (2)
Stomach carcinoma None (spontaneous) (1)