Mouse Tumor Biology Database (MTB)
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Last Database Update
2019-11-17
MTB 3.0
 
HelpHelp and Documentation Genetic Markers analyzed in the Tumor Summary  
Gene Symbol Top1
Gene Name topoisomerase (DNA) I
Mouse Chromosome 2
Genetic Change Type Insertion

Mutation Location Tumor Name Treatment Type Number of Associated Tumor Frequencies
Top1Tn(sb-Pten)1.1Jcad
topoisomerase (DNA) I; transposon insertion 1.1, Juan Cadinanos
Skin keratoacanthoma None (spontaneous) (1)
Top1Tn(sb-Pten)1.2Jcad OR Top1Tn(pb-sb-ITP)2m.1Jcad
topoisomerase (DNA) I; transposon insertion 1.2, Juan Cadinanos OR topoisomerase (DNA) I; transposon insertion 2m.1, Juan Cadinanos
Prostate gland tumor None (spontaneous) (1)
Top1Tn(sb-Pten)1.3Jcad OR Top1Tn(pb-sb-ITP)2m.2Jcad
topoisomerase (DNA) I; transposon insertion 1.3, Juan Cadinanos OR topoisomerase (DNA) I; transposon insertion 2m.2, Juan Cadinanos
Skin keratoacanthoma None (spontaneous) (1)
Top1Tn(sb-T2/Onc2)#.1Njen
topoisomerase (DNA) I; transposon insertion #.1, Nancy A Jenkins
Intestine tumor Genetic Modification (1)
Top1Tn(sb-T2/Onc2)#.2Njen
topoisomerase (DNA) I; transposon insertion #.2, Nancy A Jenkins
Mammary gland tumor None (spontaneous) (1)
Top1Tn(sb-T2/Onc2)6113.1Njen
topoisomerase (DNA) I; transposon insertion 6113.1, Nancy A Jenkins
Intestine tumor Genetic Modification (1)
Top1Tn(sb-T2/Onc3)12740.1Njen
topoisomerase (DNA) I; transposon insertion 12740.1, Nancy A Jenkins
Skin squamous cell carcinoma None (spontaneous) (1)
Top1Tn(sb-T2/Onc3)#.1Njen
topoisomerase (DNA) I; transposon insertion #.1, Nancy A Jenkins
Skin keratoacanthoma None (spontaneous) (1)
Top1Tn(sb-T2/Onc)76.1Dla
topoisomerase (DNA) I; transposon insertion 76.1, David A Largaespada
Intestine tumor None (spontaneous) (1)
Intestine tumor Chemical/Drug (1)
Top1Tn(sb-T2/Onc)76.2Dla
topoisomerase (DNA) I; transposon insertion 76.2, David A Largaespada
Intestine tumor None (spontaneous) (1)
Intestine tumor Chemical/Drug (1)